Solvation effect on photophysical and photochemical properties of mono-biotinylated curcumin

Solvent effects on photophysical and photochemical properties of mono-biotinylated curcumin (mbt-Cur) in comparison with curcumin (Cur) were studied. Same with Cur, mbt-Cur dominantly adopts 'enol-keto' configuration in all solvents stabilized by intramolecular H-bond. In non-protic solvents, the photophysical properties of mbt-Cur depend on the solvent polarity parameter Delta f. In H-bond solvent methanol, dramatic deviation of all photophysical properties from the correlation established in non-H-bond solvent occurred. H-bond capability of solvent was found to determine the excitation dynamic mechanism of mbt-Cur at a microsecond timescale. This research laid the foundation for further application of mbt-Cur in biological systems.

Automated summary

This study compared the photophysical and photochemical properties of curcumin and mono-biotinylated curcumin in different solvents, revealing the significant influence of solvent on their properties, especially the impact of the H-bond solvent methanol on mbt-Cur.