Journal
CHEMICAL PAPERS
Volume 76, Issue 1, Pages 267-275Publisher
SPRINGER INT PUBL AG
DOI: 10.1007/s11696-021-01859-6
Keywords
Phenothiazine; Fluorescence; Probe; Hydrazine; HepG2 cell
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Funding
- GZU (Guizhou University) [201909]
- State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University [FAMP202005K]
- Guizhou Science and Technology Platform Talents (QKHRCPT) [QKHRCPT [2019]5106]
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The fluorescent probe PAC, based on phenothiazine, was designed to detect hydrazine with a detection limit of 6.7 ppb. PAC demonstrated AIE properties and naked-eye recognition, with DFT calculations showing good responses to hydrazine. Cell imaging revealed PAC effectively recognized and stained hydrazine in HepG2 cells.
A new fluorescent probe (PAC) based on phenothiazine was designed and synthesized for the detection of hydrazine (N2H4), which uses methyl cyanoacetate as the recognition group and phenothiazine as the fluorescent chromophore. The Stoke shift of probe PAC at the presence of hydrazine reached to 120 nm and the detection limit of probe PAC performed as 6.7 ppb. PAC had AIE properties and provided with the functions of naked-eye recognition. The DFT and TD-DFT calculations exhibited that the probes of PAC performed good responses to hydrazine. In addition, cell imaging showed that the probe PAC effectively recognized the hydrazine in HepG2 cells and stained the cells green.
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