Journal
CHEMICAL ENGINEERING JOURNAL
Volume 414, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2021.128905
Keywords
Bioinspired; Microneedle; Hydrogel; Adhesion; Hemostasis
Categories
Funding
- National Key Research and Development Program of China [2020YFA0908200]
- National Natural Science Foundation of China [52073060, 61927805]
- Natural Science Foundation of Jiangsu [BE2018707]
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The study introduces a pagoda-like multilayer microneedle patch inspired by the hierarchical microstructure of insects, which can achieve rapid hemostasis and repair tissue injuries effectively. Its flexibility and efficiency make it a promising tool for various biomedical applications.
Efficient hemostasis is of great significance in clinical and medical fields. Herein, inspired by the hierarchical microstructure of feet or stings of insects, we present a dodecyl-modified chitosan (DCS)-coated pagoda-like multilayer microneedle patch for tissue fixation and rapid hemostasis. Such a microneedle patch is fabricated by a step-by-step mold replication, which is easy-to-operate, flexible, and highly adjustable. The multilayer structure enables the microneedle patch to strongly fix onto diverse tissues via physical interlocking and is not affected by large blood loss or other conditions; while the DCS coating can anchor onto the cell membrane, bring about blood cell coagulation, and thus actively promote hemostasis. It was demonstrated from in-vivo rabbit experiments that acute tissue injuries including liver bleeding, spleen bleeding, and kidney bleeding can be repaired immediately by employing these DCS-coated multilayer microneedle patches. These distinctive features indicate that the presented microneedle patches can find applications in hemostasis and many other biomedical fields.
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