Journal
CHEMICAL ENGINEERING JOURNAL
Volume 419, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2021.129488
Keywords
Chitin; Proanthocyanidins; Nitric Oxide; Scarless Healing
Categories
Funding
- National Key Research and Development Program of China [2018YFC0311103]
- Project of Science and Technology Innovation Cultivation for University Students of Guangdong Province [pdjh202010062]
- Science and Technology Project of Guangzhou City [2018020100]
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The chitin sponge coated with proanthocyanidins (PAs) - Cu2+ showed promising results in promoting wound healing and inhibiting scar formation. This material exhibited antioxidant and pro-vascularization activities, promoting cell proliferation and angiogenesis, inhibiting inflammation, and demonstrating efficacy in animal experiments, making it a potential dressing for scarless repair of burned skin.
Bacterial overgrowth and high oxidative stress often lead to burn wound infection, hyper-inflammation, and slowed wound healing, eventually causing scar formation. Wound dressings synergized with antibacterial, antioxidant, and pro-vascularization activities can effectively promote wound healing and inhibit scars formation. Herein, chitin sponge consisted of chitin fibers was modified by the coating of proanthocyanidins (PAs) - Cu2+ for effective scarless skin regeneration in a burn injury. The physicochemical characteristics indicated that PAs and Cu2+ successfully modified chitin sponges by the coordination between PAs and Cu2+. For one thing, PAs improved the antioxidant performance of sponges, and for another, with the help of PAs, Cu2+ effectively catalyzed S-nitrosothiols (RSNOs) to continuously generate nitric oxide (NO) in vitro/vivo for improving the inhibition of microorganisms and pro-vascularization activities. Also, Ch/PAs-Cu promoted proliferation of human umbilical vein endothelial cells (HUVECs) and rat fibroblasts (NIH-3T3), and the expression of angiogenic-related cytokines VEGF, eNOS, FGF, and MMP9. In animal experiments, Ch/PAs-Cu inhibited the accumulation of macrophages and neutrophils to regulate wound inflammation while up-regulating the expression of CD31 and alpha-SMA cytokines to promote angiogenesis. Ultimately, it promoted wound healing and inhibited scar formation. Therefore, Ch/PAs-Cu may be a promising dressing for the scarless repair of burned skin.
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