Journal
CHEMICAL ENGINEERING JOURNAL
Volume 430, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2021.131242
Keywords
Optical multiplexing detection; Single droplet detection; Upconversion; Multi-shell nanoparticle
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Funding
- Natural Nature Science Foundation of China [52072086, 51972043]
- Chinese Postdoctoral Research Fund [2018M631919]
- Applied Fundamental Research Project of Sichuan Province [2019YJ0169]
- Educational Commission of Guangdong Province [2016KQNCX163]
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In this study, upconversion multishell nanoparticles were used as nanosensors to achieve reproducible and channel-independent multiplexed detection. The constructed solid sensor demonstrated superior single-droplet multiplexed detection capability with low detection limit, high stability, and excellent recyclability.
Upconversion multiplexed optical sensors are promising in clinical diagnostics, molecular mapping and environmental monitoring. However, traditional co-doped emitter sensors and mixture sensors show poor sensitivity and reproducibility due to the strong cross-relaxation quenching and instability. Herein, upconversion multishell nanoparticles are, for the first time, applied as excitation-controlled nanosensors for reproducible and channel-independent multiplexed detection. The multi-shell structure favors the excitation-encoded reproducible blue/green/red fluorescence signals from different upconversion shells in a single upconversion nanosensor, avoiding using instable upconversion nanoparticle mixtures for multiplexed detection. A reproducible and selfcleaning solid tri-mode sensor is constructed by the upconversion multi-shell nanoparticles coated with a thin superhydrophobic SiO2 layer. The solid sensor shows superior single-droplet (approximate to 10 mu L) multiplexed detection capability with a low detection limit for dye molecules (similar to 0.1 mu g/mL), high stability and excellent recyclability (more than 100 cycles). This work provides an intriguing strategy to achieve channel-independent, reproducible UC multiplexed sensors for simultaneous detection of multi-analytes.
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