Journal
CHEMICAL ENGINEERING JOURNAL
Volume 419, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2021.129437
Keywords
Biodegradable; Shape memory; Near-infrared-II; Self-knot; Angiogenesis
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Funding
- National Key R&D Program of China [2018YFA0704000]
- National Natural Science Foundation of China [31900945, 21807074]
- Basic Research Program of Shenzhen [JCYJ20180507182413022, JCYJ20170412111100742]
- Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project [2018B030308003]
- Shenzhen Science and Technology Program [KQTD20190929172538530]
- Postdoctoral Science Foundation of China [2018M643175, 2019M653044]
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This study developed a new biodegradable NIR-II light-responsive shape memory composite by incorporating CaSiCu4O10 nanosheets. The composites showed outstanding shape memory performance under low power NIR-II laser irradiation and strong stimulation of angiogenesis due to sustained release of bioactive ions. These materials have promising potential for tissue reconstruction, especially in wound healing applications.
Near-infrared (NIR) light-responsive shape-memory composites have shown great potential in various biomedical applications due to their amazing remote actuation property. However, most of them are bioinert and restricted in NIR-I biological window. Here, we developed a new biodegradable NIR-II-responsive shape memory composite by the incorporation of CaSiCu4O10 nanosheets (CUP NSs) into shape memory polymer of poly (D, Llactide-co-trimethylene carbonate) (PDLLA-co-TMC, denoted as PT). The as-prepared CUP/PT composites possessed outstanding shape memory performance upon low power NIR-II laser irradiation (1064 nm, 0.4 W.cm- 2), offering the possibility of deep-tissue applications. Moreover, due to the sustained release of bioactive Cu2+ and SiO44- ions, the composites exhibited strong stimulation of angiogenesis both in vitro and in vivo. Our work demonstrated the promising potential of CUP/PT composites as NIR-II light-responsive biomaterials with enhanced tissue reconstruction ability, especially for wound healing.
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