Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 69, Issue 6, Pages 526-528Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c21-00179
Keywords
oxaborole; recognition; nucleic acid; photo quenching
Funding
- Kanazawa University SAKIGAKE project 2018
- Kanazawa University SAKIGAKE project 2020
- Takeda Science Foundation
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The optical properties of fluorescent unit-conjugated aliphatic oxaboroles have been studied, showing good fluorescence quantum yields and selective recognition of D-ribose and D-ribose containing molecules. Molecular recognition led to significant fluorescence quenching, suggesting the potential for a boron-based NAD sensor probe.
The optical property of fluorescent unit-conjugated aliphatic oxaboroles has been investigated. The oxaboroles provide good fluorescence quantum yields and selective recognition toward D-ribose and D-ribose containing molecules. The molecular recognition induced significant fluorescence quenching. The property of the boroles showed the possibility of the boron-based nicotinamide adenine dinucleotide (NAD) sensor probe.
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