Pyrrolactams from Marine Sponge Stylissa massa Collected from Myanmar and Their Anti-Vpr Activities

A new brominated pyrrolactam stylissaol A (1) together with four known analogues, 2-bromoaldisine, aldisine, spongiacidin D, and Z-hymenialdisine, were isolated from the EtOAc extract of marine sponge Stylissa nutssa collected in Myanmar. The absolute configuration at C-10 of 1 was determined as R by the electronic circular dichroism (ECD) data. Among the isolated compounds, 2-bromoaldisine showed anti-Viral Protein R (Vpr) activity against TREx-HeLa-Vpr cells with an effective dose of 10 mu M and its potency was comparable to that of positive control damnacanthal.

Automated summary

A new brominated pyrrolactam stylissaol A (1) and four known analogues were isolated from a marine sponge collected in Myanmar. Among them, 2-bromoaldisine exhibited anti-Vpr activity against TREx-HeLa-Vpr cells with potency comparable to that of positive control damnacanthal.