Journal
CHEMCATCHEM
Volume 13, Issue 20, Pages 4334-4341Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cctc.202100635
Keywords
Alcohols; Amination; Heterogeneous catalysis; Hydrogen; Manganese catalyst
Categories
Funding
- IISER Tirupati
- SERB, India [CRG/2018/002480/OC]
- SwarnaJayanti Fellowship [DST/SJF/CSA-04/2019-2020, SERB/F/5892/2020-2021]
- UGC
- Operational Program Research, Development and Education - European Regional Development Fund [CZ.02.1.01/0.0/0.0/16_019/0000754]
- Ministry of Education, Youth and Sports of the Czech Republic [CZ.02.1.01/0.0/0.0/17_048/0007323]
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The development of new sustainable nanocatalytic systems for green chemical synthesis is a growing area in chemical science. A reusable heterogeneous N-doped graphene-based manganese nanocatalyst for selective N-alkylation of amines with alcohols is described. Mechanistic studies illustrate that the catalytic reaction follows a domino dehydrogenation-condensation-hydrogenation sequence of alcohols and amines with the formation of water as the sole by-product. The scope of the reaction is extended to the synthesis of pharmaceutically important N-alkylated amine intermediates, and the catalyst showed long-term performance and retained its activity after several recycling experiments.
The development of new sustainable nanocatalytic systems for green chemical synthesis is a growing area in chemical science. Herein, a reusable heterogeneous N-doped graphene-based manganese nanocatalyst (Mn@NrGO) for selective N-alkylation of amines with alcohols is described. Mechanistic studies illustrate that the catalytic reaction follows a domino dehydrogenation-condensation-hydrogenation sequence of alcohols and amines with the formation of water as the sole by-product. The scope of the reaction is extended to the synthesis of pharmaceutically important N-alkylated amine intermediates. The heterogeneous nature of the catalyst made it easy to separate for long-term performance, and the recycling study revealed that the catalyst was robust and retained its activity after several recycling experiments.
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