Journal
CHEMBIOCHEM
Volume 22, Issue 21, Pages 3001-3009Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.202100274
Keywords
cyclophosphate; diamidophosphate; origins of Life; phosphorylation; prebiotic chemistry
Funding
- Simons Foundation [327124FY19]
- NASA Astrobiology Program [NNX14AP59G]
- NSF under the NSF Center for Chemical Evolution [CHE-1504217]
- NASA Astrobiology Program under the NSF Center for Chemical Evolution [CHE-1504217]
- NASA [NNX14AP59G, 674509] Funding Source: Federal RePORTER
Ask authors/readers for more resources
DAP, known since the 1890s, has shown potential as a prebiotic phosphorylating agent, with recent research highlighting its surprising versatility in enabling the emergence of various biomolecules. Systematic investigations are needed to establish its likely availability on early Earth and to develop its potential as a tool in synthetic and bioorganic chemistry.
Known since the 1890s, diamidophosphate (DAP) has been investigated within the context of its inorganic chemistry. In 1999 - with the demonstration of DAP's potential as a phosphorylating agent of sugars in aqueous medium - began the exciting phase of research about DAP's role as a plausible prebiotic phosphorylating agent. More recently, in the last five years, there has been a steady increase in the publications that have documented the surprising versatility of DAP enabling the emergence of many classes of biomolecules of life, such as nucleic acids, peptides and protocells. Thus, though in its infancy, DAP seems to be uniquely positioned to play a central role in modelling abiotic- to prebiotic-chemical evolution. In this context, there is a need for systematic investigations for: (a) establishing DAP's likely availability on the early Earth, and (b) developing DAP's potential as a tool for use in synthetic and bioorganic chemistry.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available