Journal
CHEMBIOCHEM
Volume 22, Issue 20, Pages 2914-2917Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.202100357
Keywords
genetic code expansion; host-guest molecular recognition; site-specific modification; supramolecular chemistry; unnatural amino acids
Funding
- National Natural Science Foundation of China [21922701, 21778005, 91853111]
- Beijing Natural Science Foundation [JQ20034]
- National Major Scientific and Technological Special Project for Significant New Drugs Development [2019ZX09739001]
- Shenzhen Institute of Synthetic Biology Scientific Research Program [DWKF20190004]
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Supramolecular chemistry is a promising approach for targeting proteins, utilizing genetic-code expansion and enzyme-mediated ligation to build guest recognition elements. This allows for supramolecular control of protein function and regulation.
Supramolecular chemistry for targeting proteins is of great interest for the development of novel approaches to recognize, isolate and control proteins. Taking advantage of chemical biology approaches, such as genetic-code expansion and enzyme-mediated ligation, guest recognition elements can be built into proteins of interest, allowing supramolecular control of protein function and regulation. In this viewpoint article, we will discuss the methods, applications, limitations, and future perspectives of supramolecular chemistry for targeting proteins in a site-specific manner.
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