Journal
CHEMBIOCHEM
Volume 22, Issue 22, Pages 3109-3139Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.202100171
Keywords
chemical biology; fluorophores; fluorescence; molecular probes; sensors
Funding
- NIH [5R21GM131717, 1R15CA227680]
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Fluorescent probes are widely used in various fields, and the development of new experimental designs has facilitated innovation in probe discovery methods.
Fluorescent probes have gained profound use in biotechnology, drug discovery, medical diagnostics, molecular and cell biology. The development of methods for the translation of fluorophores into fluorescent probes continues to be a robust field for medicinal chemists and chemical biologists, alike. Access to new experimental designs has enabled molecular diversification and led to the identification of new approaches to probe discovery. This review provides a synopsis of the recent lessons in modern fluorescent probe discovery.
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