Journal
CHEMBIOCHEM
Volume 22, Issue 21, Pages 3027-3036Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.202100240
Keywords
azaphilone; biosynthesis; genome mining; natural products; pathway elucidation
Funding
- MRC [MR/N029909/1]
- BBSRC [BB/V005723/1]
- BBSRC [BB/V005723/1] Funding Source: UKRI
- MRC [MR/N029909/1] Funding Source: UKRI
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Azaphilones are a family of fungal natural products with interesting and useful bioactivities. Research has identified their biosynthetic pathways and proposed a consensus scheme. Consensus understanding of core enzymatic steps can aid in genome mining experiments.
Azaphilones are a family of polyketide-based fungal natural products that exhibit interesting and useful bioactivities. This minireview explores the literature on various characterised azaphilone biosynthetic pathways, which allows for a proposed consensus scheme for the production of the core azaphilone structure, as well as identifying early diversification steps during azaphilone biosynthesis. A consensus understanding of the core enzymatic steps towards a particular family of fungal natural products can aid in genome-mining experiments. Genome mining for novel fungal natural products is a powerful technique for both exploring chemical space and providing new insights into fungal natural product pathways.
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