4.6 Article

Sex Differences in Cortical Morphometry and White Matter Microstructure During Brain Aging and Their Relationships to Cognition

Journal

CEREBRAL CORTEX
Volume 31, Issue 11, Pages 5253-5262

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhab155

Keywords

brain aging; cognition; cortical morphometry; sex difference; white matter

Categories

Funding

  1. National Key Research and Development Project of China [2018YFC1315200]
  2. National Science Fund for Distinguished Young Scholars [81625025]
  3. Funds for International Cooperation and Exchange of the National Natural Science Foundation of China [81820108034]
  4. National Natural Science Foundation of China [31700997, 82071205]
  5. Fundamental Research Funds for the Central Universities [2017XTCX04]

Ask authors/readers for more resources

The study found that both male and female brains show age-related decreases in gray and white matter volumes, with females experiencing a greater volume reduction. Additionally, stronger associations between brain structures and cognition were identified in males compared to females.
Changes in brain structure are associated with aging, and accompanied by the gradual deterioration of cognitive functions, which manifests differently in males and females. Here, we quantify the age-related spatial aging patterns of brain gray and white matter structures, their volume reduction rate, their relationships with specific cognitive functions, as well as differences between males and females in a cross-sectional nondementia dataset. We found that both males and females showed extensive age-related decreases in the volumes of most gray matter and white matter regions. Females have larger regions where the volume decreases with age and a greater slope (females: 0.199%, males: 0.183%) of volume decrease in gray matter. For white matter, no significant sex differences were found in age-related regions, and the slope of volume decrease. More significant associations were identified between brain structures and cognition in males during aging than females. This study explored the age-related regional variations in gray matter and white matter, as well as the sex differences in a nondemented elderly population. This study helps to further understand the aging of the brain structure and sex differences in the aging of brain structures and provides new evidence for the aging of nondemented individuals.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available