Melt-derived copper-doped ferrimagnetic glass-ceramic for tumor treatment

Copper-containing ferrimagnetic glass-ceramic with the following composition: 24.7% SiO2-8.5% CaO-13.5% Na2O-3.3% P2O5-31% Fe2O3-14% FeO-5CuO (wt%) was synthesized by means melt and quenching process both in powder and bulk form. The obtained samples were characterized and compared by means morphological, compositional and structural analyses. The magnetic properties and the ability to release heat were also investigated together with the antimicrobial properties towards S. aureus strain. The obtained results showed that copper introduction and the annealing process influenced the nucleation of crystalline phases; in particular the samples produced in powder form evidenced a low amount of magnetite and thus a reduced hysteresis area and ability to produce heat when exposed to an alternating magnetic field. While Cu-containing samples in the bulk form maintained the magnetic and calorimetric properties of pristine glass-ceramic. Preliminary evaluation of antibacterial properties demonstrated Cu-doped samples were not able to reduce the bacterial proliferation and thus the need to optimize the copper introduction process.

Automated summary

The study found that the introduction of copper and annealing process influenced the nucleation of crystalline phases, with samples prepared in powder form showing lower magnetite content, reduced hysteresis area, and decreased ability to produce heat when exposed to an alternating magnetic field. On the other hand, bulk samples of copper-containing materials maintained the magnetic and calorimetric properties of the original glass-ceramic. Additionally, preliminary evaluation of antibacterial properties revealed that copper-doped samples were unable to reduce bacterial proliferation, highlighting the need for optimization of the copper introduction process.