Related references
Note: Only part of the references are listed.Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements
Henry F. Thomas et al.
MOLECULAR CELL (2021)
Molecular Co-occupancy Identifies Transcription Factor Binding Cooperativity In Vivo
Can Soenmezer et al.
MOLECULAR CELL (2021)
Promoter-interacting expression quantitative trait loci are enriched for functional genetic variants
Vivek Chandra et al.
NATURE GENETICS (2021)
Promoter-proximal CTCF binding promotes distal enhancer-dependent gene activation
Naoki Kubo et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)
Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy
A. Hoernblad et al.
NATURE COMMUNICATIONS (2021)
BET inhibition disrupts transcription but retains enhancer-promoter contact
Nicholas T. Crump et al.
NATURE COMMUNICATIONS (2021)
ZNF143 mediates CTCF-bound promoter-enhancer loops required for murine hematopoietic stem and progenitor cell function
Qiling Zhou et al.
NATURE COMMUNICATIONS (2021)
Three-dimensional interactions between enhancers and promoters during intestinal differentiation depend upon HNF4
Lei Chen et al.
CELL REPORTS (2021)
Chromatin Looping Links Target Genes with Genetic Risk Loci for Dermatological Traits
Chenfu Shi et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)
Pioneering the developmental frontier
Elizabeth D. Larson et al.
MOLECULAR CELL (2021)
Cooperative binding between distant transcription factors is a hallmark of active enhancers
Satyanarayan Rao et al.
MOLECULAR CELL (2021)
Regulatory genomic circuitry of human disease loci by integrative epigenomics
Carles A. Boix et al.
NATURE (2021)
Base-resolution models of transcription-factor binding reveal soft motif syntax
Ziga Avsec et al.
NATURE GENETICS (2021)
Heart Enhancers: Development and Disease Control at a Distance
Xuefei Yuan et al.
FRONTIERS IN GENETICS (2021)
Bridging-induced phase separation induced by cohesin SMC protein complexes
Je-Kyung Ryu et al.
SCIENCE ADVANCES (2021)
Transcriptional Regulation by (Super)Enhancers: From Discovery to Mechanisms
Frank Grosveld et al.
Annual Review of Genomics and Human Genetics (2021)
Enhancer-promoter communication: hubs or loops?
Bomyi Lim et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2021)
Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release
Takeo Narita et al.
MOLECULAR CELL (2021)
Genome-wide enhancer maps link risk variants to disease genes
Joseph Nasser et al.
NATURE (2021)
Single-cell CUT&Tag profiles histone modifications and transcription factors in complex tissues
Marek Bartosovic et al.
NATURE BIOTECHNOLOGY (2021)
Cis-regulatory chromatin loops arise before TADs and gene activation, and are independent of cell fate during early Drosophila development
Sergio Martin Espinola et al.
NATURE GENETICS (2021)
Ultraconserved enhancer function does not require perfect sequence conservation
Valentina Snetkova et al.
NATURE GENETICS (2021)
Independence of chromatin conformation and gene regulation during Drosophila dorsoventral patterning
Elizabeth Ing-Simmons et al.
NATURE GENETICS (2021)
Histone acetylation dynamics modulates chromatin conformation and allele-specific interactions at oncogenic loci
Stephanie Sungalee et al.
NATURE GENETICS (2021)
Identifying high-confidence capture Hi-C interactions using CHiCANE
Erle M. Holgersen et al.
NATURE PROTOCOLS (2021)
A model of active transcription hubs that unifies the roles of active promoters and enhancers
Iris Zhu et al.
NUCLEIC ACIDS RESEARCH (2021)
Enhancer rewiring in tumors: an opportunity for therapeutic intervention
Laia Richart et al.
ONCOGENE (2021)
Widespread reorganisation of pluripotent factor binding and gene regulatory interactions between human pluripotent states
Peter Chovanec et al.
NATURE COMMUNICATIONS (2021)
Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease
Stephen Watt et al.
NATURE COMMUNICATIONS (2021)
An interdependent network of functional enhancers regulates transcription and EZH2 loading at the INK4a/ARF locus
Umer Farooq et al.
CELL REPORTS (2021)
Evidence for additive and synergistic action of mammalian enhancers during cell fate determination
Jinmi Choi et al.
ELIFE (2021)
Multi-Dimensional Gene Regulation in Innate and Adaptive Lymphocytes: A View From Regulomes
Nilisha Fernando et al.
FRONTIERS IN IMMUNOLOGY (2021)
Deciphering the Complexity of 3D Chromatin Organization Driving Lymphopoiesis and Lymphoid Malignancies
Laurianne Scourzic et al.
FRONTIERS IN IMMUNOLOGY (2021)
Defining genome architecture at base-pair resolution
Peng Hua et al.
NATURE (2021)
Enhancer release and retargeting activates disease-susceptibility genes
Soohwan Oh et al.
NATURE (2021)
Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness
Tomas Pachano et al.
NATURE GENETICS (2021)
The nuclear periphery is a scaffold for tissue-specific enhancers
Cheryl L. Smith et al.
NUCLEIC ACIDS RESEARCH (2021)
The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo
Giuliano Crispatzu et al.
NATURE COMMUNICATIONS (2021)
High-throughput single-cell chromatin accessibility CRISPR screens enable unbiased identification of regulatory networks in cancer
Sarah E. Pierce et al.
NATURE COMMUNICATIONS (2021)
The global and promoter-centric 3D genome organization temporally resolved during a circadian cycle
Mayra Furlan-Magaril et al.
GENOME BIOLOGY (2021)
Mechanisms of enhancer action: the known and the unknown
Anil Panigrahi et al.
GENOME BIOLOGY (2021)
Transcriptional Silencers in Drosophila Serve a Dual Role as Transcriptional Enhancers in Alternate Cellular Contexts
Stephen S. Gisselbrecht et al.
MOLECULAR CELL (2020)
Determinants of enhancer and promoter activities of regulatory elements
Robin Andersson et al.
NATURE REVIEWS GENETICS (2020)
Chromatin interaction analyses elucidate the roles of PRC2-bound silencers in mouse development
Chew Yee Ngan et al.
NATURE GENETICS (2020)
Identifying statistically significant chromatin contacts from Hi-C data with FitHiC2
Arya Kaul et al.
NATURE PROTOCOLS (2020)
Direct and simultaneous observation of transcription and chromosome architecture in single cells with Hi-M
Andres M. Cardozo Gizzi et al.
NATURE PROTOCOLS (2020)
Functional effects of variation in transcription factor binding highlight long-range gene regulation by epromoters
Joanna Mitchelmore et al.
NUCLEIC ACIDS RESEARCH (2020)
Advances in Chromatin Imaging at Kilobase-Scale Resolution
Alistair Boettiger et al.
TRENDS IN GENETICS (2020)
What Is a Transcriptional Burst?
Edward Tunnacliffe et al.
TRENDS IN GENETICS (2020)
Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing
Kailong Li et al.
NATURE COMMUNICATIONS (2020)
Widespread activation of developmental gene expression characterized by PRC1-dependent chromatin looping
V Loubiere et al.
SCIENCE ADVANCES (2020)
Diversity and Emerging Roles of Enhancer RNA in Regulation of Gene Expression and Cell Fate
Preston R. Arnold et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)
Hi-C Identifies Complex Genomic Rearrangements and TAD-Shuffling in Developmental Diseases
Uira Souto Melo et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2020)
Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells
James D. P. Rhodes et al.
CELL REPORTS (2020)
Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31
Helen Ray-Jones et al.
BMC BIOLOGY (2020)
Unblending of Transcriptional Condensates in Human Repeat Expansion Disease
Shaon Basu et al.
CELL (2020)
Dynamics of the 4D genome during in vivo lineage specification and differentiation
A. Marieke Oudelaar et al.
NATURE COMMUNICATIONS (2020)
Resolving the 3D Landscape of Transcription-Linked Mammalian Chromatin Folding
Tsung-Han S. Hsieh et al.
MOLECULAR CELL (2020)
Ultrastructural Details of Mammalian Chromosome Architecture
Nils Krietenstein et al.
MOLECULAR CELL (2020)
Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function
Svetlana O. Dodonova et al.
NATURE (2020)
The Interplay between Phase Separation and Gene-Enhancer Communication: A Theoretical Study
Andrea M. Chiariello et al.
BIOPHYSICAL JOURNAL (2020)
Index and biological spectrum of human DNase I hypersensitive sites
Wouter Meuleman et al.
NATURE (2020)
Expanded encyclopaedias of DNA elements in the human and mouse genomes
Jill E. Moore et al.
NATURE (2020)
Supervised enhancer prediction with epigenetic pattern recognition and targeted validation
Anurag Sethi et al.
NATURE METHODS (2020)
Regulation of spatiotemporal limits of developmental gene expression via enhancer grammar
Samuel H. Keller et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Single-molecule regulatory architectures captured by chromatin fiber sequencing
Andrew B. Stergachis et al.
SCIENCE (2020)
Biomolecular Condensates in the Nucleus
Benjamin R. Sabari et al.
TRENDS IN BIOCHEMICAL SCIENCES (2020)
Nucleosome binding by the pioneer transcription factor OCT4
Kenta Echigoya et al.
SCIENTIFIC REPORTS (2020)
Cohesin-Dependent and -Independent Mechanisms Mediate Chromosomal Contacts between Promoters and Enhancers
Michiel J. Thiecke et al.
CELL REPORTS (2020)
Lentiviral delivery of combinatorial CAR/CRISPRi circuit into human primary T cells is enhanced by TBK1/IKKe complex inhibitor BX795
Lingyu Li et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2020)
Predicting 3D genome folding from DNA sequence with Akita
Geoff Fudenberg et al.
NATURE METHODS (2020)
A modified protocol of Capture-C allows affordable and flexible high-resolution promoter interactome analysis
Arkadiy K. Golov et al.
SCIENTIFIC REPORTS (2020)
Phase-Separated Transcriptional Condensates Accelerate Target-Search Process Revealed by Live-Cell Single-Molecule Imaging
Samantha Kent et al.
CELL REPORTS (2020)
Deep conservation of the enhancer regulatory code in animals
Emily S. Wong et al.
SCIENCE (2020)
Learning and interpreting the gene regulatory grammar in a deep learning framework
Ling Chen et al.
PLOS COMPUTATIONAL BIOLOGY (2020)
Spatial patterns of CTCF sites define the anatomy of TADs and their boundaries
Luca Nanni et al.
GENOME BIOLOGY (2020)
Histone H3K27 acetylation is dispensable for enhancer activity in mouse embryonic stem cells
Tiantian Zhang et al.
GENOME BIOLOGY (2020)
The mechanistic basis for chromatin regulation by pioneer transcription factors
Makiko Iwafuchi-Doi
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE (2019)
Extensive Heterogeneity and Intrinsic Variation in Spatial Genome Organization
Elizabeth H. Finn et al.
CELL (2019)
Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates
Simon Alberti et al.
CELL (2019)
Microscopy-Based Chromosome Conformation Capture Enables Simultaneous Visualization of Genome Organization and Transcription in Intact Organisms
Andres M. Cardozo Gizzi et al.
MOLECULAR CELL (2019)
Visualizing DNA folding and RNA in embryos at single-cell resolution
Leslie J. Mateo et al.
NATURE (2019)
Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression
William W. Greenwald et al.
NATURE COMMUNICATIONS (2019)
Signal Integration by Shadow Enhancers and Enhancer Duplications Varies across the Drosophila Embryo
Clarissa Scholes et al.
CELL REPORTS (2019)
Profiling of Pluripotency Factors in Single Cells and Early Embryos
Sarah J. Hainer et al.
CELL (2019)
The Drosophila Pioneer Factor Zelda Modulates the Nuclear Microenvironment of a Dorsal Target Enhancer to Potentiate Transcriptional Output
Shigehiro Yamada et al.
CURRENT BIOLOGY (2019)
Long-range enhancer-promoter contacts in gene expression control
Stefan Schoenfelder et al.
NATURE REVIEWS GENETICS (2019)
Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity
Jeffrey M. Alexander et al.
ELIFE (2019)
Cohesion and cohesin-dependent chromatin organization
Tomoko Nishiyama
CURRENT OPINION IN CELL BIOLOGY (2019)
Heterochromatin drives compartmentalization of inverted and conventional nuclei
Martin Falk et al.
NATURE (2019)
Highly rearranged chromosomes reveal uncoupling between genome topology and gene expression
Yad Ghavi-Helm et al.
NATURE GENETICS (2019)
LADL: light-activated dynamic looping for endogenous gene expression control
Ji Hun Kim et al.
NATURE METHODS (2019)
Preformed chromatin topology assists transcriptional robustness of Shh during limb development
Christina Paliou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Large distances separate coregulated genes in living Drosophila embryos
Tyler Heist et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Enhancer accessibility and CTCF occupancy underlie asymmetric TAD architecture and cell type specific genome topology
Christopher Barrington et al.
NATURE COMMUNICATIONS (2019)
Pax3 cooperates with Ldb1 to direct local chromosome architecture during myogenic lineage specification
Alessandro Magli et al.
NATURE COMMUNICATIONS (2019)
CUT&Tag for efficient epigenomic profiling of small samples and single cells
Hatice S. Kaya-Okur et al.
NATURE COMMUNICATIONS (2019)
A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers
Laila El Khattabi et al.
CELL (2019)
Chromatin topology, condensates and gene regulation: shifting paradigms or just a phase?
Mustafa Mir et al.
DEVELOPMENT (2019)
Enhancer Features that Drive Formation of Transcriptional Condensates
Krishna Shrinivas et al.
MOLECULAR CELL (2019)
Decreased Enhancer-Promoter Proximity Accompanying Enhancer Activation
Nezha S. Benabdallah et al.
MOLECULAR CELL (2019)
Pol II phosphorylation regulates a switch between transcriptional and splicing condensates
Yang Eric Guo et al.
NATURE (2019)
RNA polymerases as moving barriers to condensin loop extrusion
Hugo B. Brandao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Analysis of Promoter-Associated Chromatin Interactions Reveals Biologically Relevant Candidate Target Genes at Endometrial Cancer Risk Loci
Tracy A. O'Mara et al.
CANCERS (2019)
Organization of Chromatin by Intrinsic and Regulated Phase Separation
Bryan A. Gibson et al.
CELL (2019)
Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences
David T. McSwiggen et al.
GENES & DEVELOPMENT (2019)
HP1 reshapes nucleosome core to promote phase separation of heterochromatin
S. Sanulli et al.
NATURE (2019)
Chromatin structure dynamics during the mitosis-to-G1 phase transition
Haoyue Zhang et al.
NATURE (2019)
Activity-by-contact model of enhancer-promoter regulation from thousands of CRISPR perturbations
Charles P. Fulco et al.
NATURE GENETICS (2019)
Liquid-liquid phase separation is an intrinsic physicochemical property of chromatin
Yi Zhang et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)
DNA loop extrusion by human cohesin
Iain F. Davidson et al.
SCIENCE (2019)
Human cohesin compacts DNA by loop extrusion
Yoori Kim et al.
SCIENCE (2019)
Brain cell type-specific enhancer-promoter interactome maps and disease-risk association
Alexi Nott et al.
SCIENCE (2019)
Identification of significant chromatin contacts from HiChIP data by FitHiChIP
Sourya Bhattacharyya et al.
NATURE COMMUNICATIONS (2019)
A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus
A. Marieke Oudelaar et al.
NATURE COMMUNICATIONS (2019)
Gene expression models based on transcription factor binding events confer insight into functional cis-regulatory variants
Wenqiang Shi et al.
BIOINFORMATICS (2019)
Genomic encoding of transcriptional burst kinetics
Anton J. M. Larsson et al.
NATURE (2019)
LHX2-and LDB1-mediated trans interactions regulate olfactory receptor choice
Kevin Monahan et al.
NATURE (2019)
High-resolution genetic mapping of putative causal interactions between regions of open chromatin
Natsuhiko Kumasaka et al.
NATURE GENETICS (2019)
C1 CAGE detects transcription start sites and enhancer activity at single-cell resolution
Tsukasa Kouno et al.
NATURE COMMUNICATIONS (2019)
Fine-mapping cis-regulatory variants in diverse human populations
Ashley Tehranchi et al.
ELIFE (2019)
The first enhancer in an enhancer chain safeguards subsequent enhancer-promoter contacts from a distance
Wei Song et al.
GENOME BIOLOGY (2019)
Vireo: Bayesian demultiplexing of pooled single-cell RNA-seq data without genotype reference
Yuanhua Huang et al.
GENOME BIOLOGY (2019)
Common DNA sequence variation influences 3-dimensional conformation of the human genome
David U. Gorkin et al.
GENOME BIOLOGY (2019)
Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density
Alessandra Chesi et al.
NATURE COMMUNICATIONS (2019)
Multiplexed droplet single-cell RNA-sequencing using natural genetic variation
Hyun Min Kang et al.
NATURE BIOTECHNOLOGY (2018)
Transcription regulation by the Mediator complex
Julie Soutourina
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)
Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay (vol 165, pg 1519, 2016)
Ryan Tewhey et al.
CELL (2018)
Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the Nucleus
Sofia A. Quinodoz et al.
CELL (2018)
The Energetics and Physiological Impact of Cohesin Extrusion
Laura Vian et al.
CELL (2018)
Histone H3 lysine 4 monomethylation modulates long-range chromatin interactions at enhancers
Jian Yan et al.
CELL RESEARCH (2018)
A feed-forward relay integrates the regulatory activities of Bicoid and Orthodenticle via sequential binding to suboptimal sites
Rhea R. Datta et al.
GENES & DEVELOPMENT (2018)
Widespread transcriptional pausing and elongation control at enhancers
Telmo Henriques et al.
GENES & DEVELOPMENT (2018)
The degree of enhancer or promoter activity is reflected by the levels and directionality of eRNA transcription
Olga Mikhaylichenko et al.
GENES & DEVELOPMENT (2018)
Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cells
Akiko Seki et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2018)
Visualization of Transvection in Living Drosophila Embryos
Bomyi Lim et al.
MOLECULAR CELL (2018)
A Muscle-Specific Enhancer RNA Mediates Cohesin Recruitment and Regulates Transcription In trans
Pei-Fang Tsai et al.
MOLECULAR CELL (2018)
Polycomb-Dependent Chromatin Looping Contributes to Gene Silencing during Drosophila Development
Yuki Ogiyama et al.
MOLECULAR CELL (2018)
The transcription factor Grainy head primes epithelial enhancers for spatiotemporal activation by displacing nucleosomes
Jelle Jacobs et al.
NATURE GENETICS (2018)
Enhancer hubs and loop collisions identified from single-allele topologies
Amin Allahyar et al.
NATURE GENETICS (2018)
Genetic determinants of co-accessible chromatin regions in activated T cells across humans
Rachel E. Gate et al.
NATURE GENETICS (2018)
Chromatin organization by an interplay of loop extrusion and compartmental segregation
Johannes Nuebler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Imaging dynamic and selective low-complexity domain interactions that control gene transcription
Shasha Chong et al.
SCIENCE (2018)
Transcription-coupled changes in nuclear mobility of mammalian cis-regulatory elements
Bo Gu et al.
SCIENCE (2018)
Sex reversal following deletion of a single distal enhancer of Sox9
Nitzan Gonen et al.
SCIENCE (2018)
Coactivator condensation at super-enhancers links phase separation and gene control
Benjamin R. Sabari et al.
SCIENCE (2018)
Mediator and RNA polymerase II clusters associate in transcription-dependent condensates
Won-Ki Cho et al.
SCIENCE (2018)
Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks
Richard C. Pelikan et al.
NATURE COMMUNICATIONS (2018)
Long-Range Enhancer Interactions Are Prevalent in Mouse Embryonic Stem Cells and Are Reorganized upon Pluripotent State Transition
Clara Lopes Novo et al.
CELL REPORTS (2018)
Determining the genetic basis of anthracycline-cardiotoxicity by molecular response QTL mapping in induced cardiomyocytes
David A. Knowlest et al.
ELIFE (2018)
A transcription factor collective defines the HSN serotonergic neuron regulatory landscape
Carla Lloret-Fernandez et al.
ELIFE (2018)
A promoter interaction map for cardiovascular disease genetics
Lindsey E. Montefiori et al.
ELIFE (2018)
Transcription Elongation Can Affect Genome 3D Structure
Sven Heinz et al.
CELL (2018)
ZNF143 is a regulator of chromatin loop
Zi Wen et al.
CELL BIOLOGY AND TOXICOLOGY (2018)
Enhancer redundancy provides phenotypic robustness in mammalian development
Marco Osterwalder et al.
NATURE (2018)
Dynamic interplay between enhancer-promoter topology and gene activity
Hongtao Chen et al.
NATURE GENETICS (2018)
Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation
Sergi Cuartero et al.
NATURE IMMUNOLOGY (2018)
RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation
Homa Rahnamoun et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)
D Repurposing of promoters and enhancers during mammalian evolution
Francesco N. Carelli et al.
NATURE COMMUNICATIONS (2018)
Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation
Ryan Raisner et al.
CELL REPORTS (2018)
CRISPR-Mediated Reorganization of Chromatin Loop Structure
Stefanie L. Morgan et al.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2018)
Dichotomy in redundant enhancers points to presence of initiators of gene regulation
Wei Song et al.
BMC GENOMICS (2018)
Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains
Ann Boija et al.
CELL (2018)
SLIC-CAGE: high-resolution transcription start site mapping using nanogram-levels of total RNA
Nevena Cvetesic et al.
GENOME RESEARCH (2018)
Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains
A. Marieke Oudelaar et al.
NATURE GENETICS (2018)
Guide Swap enables genome-scale pooled CRISPR-Cas9 screening in human primary cells
Pamela Y. Ting et al.
NATURE METHODS (2018)
The chromatin accessibility landscape of primary human cancers
M. Ryan Corces et al.
SCIENCE (2018)
Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells
Bogdan Bintu et al.
SCIENCE (2018)
Divergent wiring of repressive and active chromatin interactions between mouse embryonic and trophoblast lineages
Stefan Schoenfelder et al.
NATURE COMMUNICATIONS (2018)
Temporal control of gene expression by the pioneer factor Zelda through transient interactions in hubs
Jeremy Dufourt et al.
NATURE COMMUNICATIONS (2018)
Walking along chromosomes with super-resolution imaging, contact maps, and integrative modeling
Guy Nir et al.
PLOS GENETICS (2018)
Dynamic multifactor hubs interact transiently with sites of active transcription in Drosophila embryos
Mustafa Mir et al.
ELIFE (2018)
Developmental enhancers and chromosome topology
Eileen E. M. Furlong et al.
SCIENCE (2018)
SNP2TFBS-a database of regulatory SNPs affecting predicted transcription factor binding site affinity
Sunil Kumar et al.
NUCLEIC ACIDS RESEARCH (2017)
Dense Bicoid hubs accentuate binding along the morphogen gradient
Mustafa Mir et al.
GENES & DEVELOPMENT (2017)
Constrained release of lamina-associated enhancers and genes from the nuclear envelope during T-cell activation facilitates their association in chromosome compartments
Michael I. Robson et al.
GENOME RESEARCH (2017)
Reciprocal insulation analysis of Hi-C data shows that TADs represent a functionally but not structurally privileged scale in the hierarchical folding of chromosomes
Yinxiu Zhan et al.
GENOME RESEARCH (2017)
YY1 and CTCF orchestrate a 3D chromatin looping switch during early neural lineage commitment
Jonathan A. Beagan et al.
GENOME RESEARCH (2017)
AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection
Thomas Vierbuchen et al.
MOLECULAR CELL (2017)
Multiplexed Engineering and Analysis of Combinatorial Enhancer Activity in Single Cells
Shiqi Xie et al.
MOLECULAR CELL (2017)
Genome-wide Single-Molecule Footprinting Reveals High RNA Polymerase II Turnover at Paused Promoters
Arnaud R. Krebs et al.
MOLECULAR CELL (2017)
Dynamic Rewiring of Promoter-Anchored Chromatin Loops during Adipocyte Differentiation
Rasmus Siersbaek et al.
MOLECULAR CELL (2017)
Two independent modes of chromatin organization revealed by cohesin removal
Wibke Schwarzer et al.
NATURE (2017)
Complex multi-enhancer contacts captured by genome architecture mapping
Robert A. Beagrie et al.
NATURE (2017)
Is a super-enhancer greater than the sum of its parts?
Noah Dukler et al.
NATURE GENETICS (2017)
Genome-wide characterization of mammalian promoters with distal enhancer functions
Lan T. M. Dao et al.
NATURE GENETICS (2017)
Lineage-specific dynamic and pre-established enhancer-promoter contacts cooperate in terminal differentiation
Adam J. Rubin et al.
NATURE GENETICS (2017)
Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements
Maxwell R. Mumbach et al.
NATURE GENETICS (2017)
A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells
Yarui Diao et al.
NATURE METHODS (2017)
FISHing for captured contacts: towards reconciling FISH and 3C
Geoffrey Fudenberg et al.
NATURE METHODS (2017)
Pooled CRISPR screening with single-cell transcriptome readout
Paul Datlinger et al.
NATURE METHODS (2017)
Polycomb-mediated chromatin loops revealed by a subkilobase-resolution chromatin interaction map
Kyle P. Eagen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Multi-scale chromatin state annotation using a hierarchical hidden Markov model
Eugenio Marco et al.
NATURE COMMUNICATIONS (2017)
The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers
Burak H. Alver et al.
NATURE COMMUNICATIONS (2017)
The Conserved Sonic Hedgehog Limb Enhancer Consists of Discrete Functional Elements that Regulate Precise Spatial Expression
Laura A. Lettice et al.
CELL REPORTS (2017)
Glucocorticoid Receptor Binding Induces Rapid and Prolonged Large-Scale Chromatin Decompaction at Multiple Target Loci
Alasdair W. Jubb et al.
CELL REPORTS (2017)
Super-resolution imaging of a 2.5 kb non-repetitive DNA in situ in the nuclear genome using molecular beacon probes
Yanxiang Ni et al.
ELIFE (2017)
Uncoupling evolutionary changes in DNA sequence, transcription factor occupancy and enhancer activity
Pierre Khoueiry et al.
ELIFE (2017)
The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatroy element funciton in mouse embryonic stem cells
Hamish W. King et al.
ELIFE (2017)
An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites
Peter J. Skene et al.
ELIFE (2017)
Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells
Paula Freire-Pritchett et al.
ELIFE (2017)
Pancreatic Agenesis due to Compound Heterozygosity for a Novel Enhancer and Truncating Mutation in the PTF1A Gene
Monica Gabbay et al.
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY (2017)
YY1 Is a Structural Regulator of Enhancer-Promoter Loops
Abraham S. Weintraub et al.
CELL (2017)
Single-cell Hi-C bridges microscopy and genome-wide sequencing approaches to study 3D chromatin organization
Sergey V. Ulianov et al.
BIOESSAYS (2017)
Multiscale 3D Genome Rewiring during Mouse Neural Development
Boyan Bonev et al.
CELL (2017)
Cohesin Loss Eliminates All Loop Domains
Suhas S. P. Rao et al.
CELL (2017)
Chromosome contacts in activated T cells identify autoimmune disease candidate genes
Oliver S. Burren et al.
GENOME BIOLOGY (2017)
Targeted Degradation of CTCF Decouples Local Insulation of Chromosome Domains from Genomic Compartmentalization
Elphege P. Nora et al.
CELL (2017)
Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression
Bas van Steensel et al.
CELL (2017)
PRC2 Facilitates the Regulatory Topology Required for Poised Enhancer Function during Pluripotent Stem Cell Differentiation
Sara Cruz-Molina et al.
CELL STEM CELL (2017)
Chromatin Architecture Emerges during Zygotic Genome Activation Independent of Transcription
Clemens B. Hug et al.
CELL (2017)
A Phase Separation Model for Transcriptional Control
Denes Hnisz et al.
CELL (2017)
Multiplexed analysis of chromosome conformation at vastly improved sensitivity
James O. J. Davies et al.
NATURE METHODS (2016)
Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters
Biola M. Javierre et al.
CELL (2016)
Pooled ChIP-Seq Links Variation in Transcription Factor Binding to Complex Disease Risk
Ashley K. Tehranchi et al.
CELL (2016)
Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells
Lu Chen et al.
CELL (2016)
Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq
Diego Adhemar Jaitin et al.
CELL (2016)
Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens
Atray Dixit et al.
CELL (2016)
A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response
Britt Adamson et al.
CELL (2016)
Enhancer Control of Transcriptional Bursting
Takashi Fukaya et al.
CELL (2016)
Ever-Changing Landscapes: Transcriptional Enhancers in Development and Evolution
Hannah K. Long et al.
CELL (2016)
Mapping of long-range chromatin interactions by proximity ligation-assisted ChIP-seq
Rongxin Fang et al.
CELL RESEARCH (2016)
3D Chromosome Regulatory Landscape of Human Pluripotent Cells
Xiong Ji et al.
CELL STEM CELL (2016)
Shadow Enhancers Are Pervasive Features of Developmental Regulatory Networks
Enrico Cannavo et al.
CURRENT BIOLOGY (2016)
The Shh Topological Domain Facilitates the Action of Remote Enhancers by Reducing the Effects of Genomic Distances
Orsolya Symmons et al.
DEVELOPMENTAL CELL (2016)
High-throughput functional comparison of promoter and enhancer activities
Thomas A. Nguyen et al.
GENOME RESEARCH (2016)
ZNF143 Is Involved in CTCF-Mediated Chromatin Interactions by Cooperation with Cohesin and Other Partners
B. -Y. Ye et al.
MOLECULAR BIOLOGY (2016)
The Pioneer Transcription Factor FoxA Maintains an Accessible Nucleosome Configuration at Enhancers for Tissue-Specific Gene Activation
Makiko Iwafuchi-Doi et al.
MOLECULAR CELL (2016)
Chromatin Domains: The Unit of Chromosome Organization
Jesse R. Dixon et al.
MOLECULAR CELL (2016)
Enhancer Regulation of Transcriptional Bursting Parameters Revealed by Forced Chromatin Looping
Caroline R. Bartman et al.
MOLECULAR CELL (2016)
Local regulation of gene expression by lncRNA promoters, transcription and splicing
Jesse M. Engreitz et al.
NATURE (2016)
Quantitatively predictable control of Drosophila transcriptional enhancers in vivo with engineered transcription factors
Justin Crocker et al.
NATURE GENETICS (2016)
Principles for RNA metabolism and alternative transcription initiation within closely spaced promoters
Yun Chen et al.
NATURE GENETICS (2016)
Hierarchy within the mammary STAT5-driven Wap super-enhancer
Ha Youn Shin et al.
NATURE GENETICS (2016)
Genetic dissection of the α-globin super-enhancer in vivo
Deborah Hay et al.
NATURE GENETICS (2016)
Histone H3 globular domain acetylation identifies a new class of enhancers
Madapura M. Pradeepa et al.
NATURE GENETICS (2016)
Micro-C XL: assaying chromosome conformation from the nucleosome to the entire genome
Tsung-Han S. Hsieh et al.
NATURE METHODS (2016)
HiChIP: efficient and sensitive analysis of protein-directed genome architecture
Maxwell R. Mumbach et al.
NATURE METHODS (2016)
Epstein-Barr virus super-enhancer eRNAs are essential for MYC oncogene expression and lymphoblast proliferation
Jun Liang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Systematic mapping of functional enhancer-promoter connections with CRISPR interference
Charles P. Fulco et al.
SCIENCE (2016)
Regulatory Enhancer-Core-Promoter Communication via Transcription Factors and Cofactors
Muhammad A. Zabidi et al.
TRENDS IN GENETICS (2016)
Breaking TADs: How Alterations of Chromatin Domains Result in Disease
Dario G. Lupianez et al.
TRENDS IN GENETICS (2016)
Cajal bodies are linked to genome conformation
Qiuyan Wang et al.
NATURE COMMUNICATIONS (2016)
Formation of Chromosomal Domains by Loop Extrusion
Geoffrey Fudenberg et al.
CELL REPORTS (2016)
A Hox Transcription Factor Collective Binds a Highly Conserved Distal-less cis-Regulatory Module to Generate Robust Transcriptional Outcomes
Juli D. Uhl et al.
PLOS GENETICS (2016)
RNA Polymerase II cluster dynamics predict mRNA output in living cells
Won-Ki Cho et al.
ELIFE (2016)
GATA3-dependent cellular reprogramming requires activation-domain dependent recruitment of a chromatin remodeler
Motoki Takaku et al.
GENOME BIOLOGY (2016)
Genome-wide identification of Drosophila dorso-ventral enhancers by differential histone acetylation analysis
Nina Koenecke et al.
GENOME BIOLOGY (2016)
Closing the loop: 3C versus DNA FISH
Luca Giorgetti et al.
GENOME BIOLOGY (2016)
CHiCAGO: robust detection of DNA looping interactions in Capture Hi-C data
Jonathan Cairns et al.
GENOME BIOLOGY (2016)
Enhancers, enhancers - from their discovery to today's universe of transcription enhancers
Walter Schaffner
BIOLOGICAL CHEMISTRY (2015)
Functionally conserved enhancers with divergent sequences in distant vertebrates
Song Yang et al.
BMC GENOMICS (2015)
Genetic Control of Chromatin States in Humans Involves Local and Distal Chromosomal Interactions
Fabian Grubert et al.
CELL (2015)
Enhancer Evolution across 20 Mammalian Species
Diego Villar et al.
CELL (2015)
Low Affinity Binding Site Clusters Confer Hox Specificity and Regulatory Robustness
Justin Crocker et al.
CELL (2015)
Population Variation and Genetic Control of Modular Chromatin Architecture in Humans
Sebastian M. Waszak et al.
CELL (2015)
Mapping Nucleosome Resolution Chromosome Folding in Yeast by Micro-C
Tsung-Han S. Hsieh et al.
CELL (2015)
Disruptions of Topological Chromatin Domains Cause Pathogenic Rewiring of Gene-Enhancer Interactions
Dario G. Lupianez et al.
CELL (2015)
CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function
Ya Guo et al.
CELL (2015)
The Role of Chromosome Domains in Shaping the Functional Genome
Tom Sexton et al.
CELL (2015)
Spatial enhancer clustering and regulation of enhancer-proximal genes by cohesin
Elizabeth Ing-Simmons et al.
GENOME RESEARCH (2015)
Zelda is differentially required for chromatin accessibility, transcription factor binding, and gene expression in the early Drosophila embryo
Katharine N. Schulz et al.
GENOME RESEARCH (2015)
The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements
Stefan Schoenfelder et al.
GENOME RESEARCH (2015)
CTCF Binding Polarity Determines Chromatin Looping
Elzo de Wit et al.
MOLECULAR CELL (2015)
Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles
Timothy J. Nott et al.
MOLECULAR CELL (2015)
Chromatin architecture reorganization during stem cell differentiation
Jesse R. Dixon et al.
NATURE (2015)
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
Isaac B. Hilton et al.
NATURE BIOTECHNOLOGY (2015)
Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome
Stefan Schoenfelder et al.
NATURE GENETICS (2015)
Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C
Borbala Mifsud et al.
NATURE GENETICS (2015)
The Mediator complex: a central integrator of transcription
Benjamin L. Allen et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)
Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes
Adrian L. Sanborn et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics
Shana Elbaum-Garfinkle et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Suboptimization of developmental enhancers
Emma K. Farley et al.
SCIENCE (2015)
Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci
Paul Martin et al.
NATURE COMMUNICATIONS (2015)
Single-molecule super-resolution imaging of chromosomes and in situ haplotype visualization using Oligopaint FISH probes
Brian J. Beliveau et al.
NATURE COMMUNICATIONS (2015)
Cross-Population Joint Analysis of eQTLs: Fine Mapping and Functional Annotation
Xiaoquan Wen et al.
PLOS GENETICS (2015)
Enhancer additivity and non-additivity are determined by enhancer strength in the Drosophila embryo
Jacques P. Bothma et al.
ELIFE (2015)
Regulation of gene transcription by Polycomb proteins
Sergi Aranda et al.
SCIENCE ADVANCES (2015)
Enhancer-core-promoter specificity separates developmental and housekeeping gene regulation
Muhammad A. Zabidi et al.
NATURE (2015)
ZNF143 provides sequence specificity to secure chromatin interactions at gene promoters
Swneke D. Bailey et al.
NATURE COMMUNICATIONS (2015)
A novel ATAC-seq approach reveals lineage-specific reinforcement of the open chromatin landscape via cooperation between BAF and p63
Xiaomin Bao et al.
GENOME BIOLOGY (2015)
Liquid-Liquid Phase Separation in Biology
Anthony A. Hyman et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30 (2014)
Spurious transcription factor binding: Non-functional or genetically redundant?
Mikhail Spivakov
BIOESSAYS (2014)
Reactivation of Developmentally Silenced Globin Genes by Forced Chromatin Looping
Wulan Deng et al.
CELL (2014)
Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells
Jiji Chen et al.
CELL (2014)
Enhancer Interaction Networks as a Means for Singular Olfactory Receptor Expression
Eirene Markenscoff-Papadimitriou et al.
CELL (2014)
A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping
Suhas S. P. Rao et al.
CELL (2014)
Control of Cell Identity Genes Occurs in Insulated Neighborhoods in Mammalian Chromosomes
Jill M. Dowen et al.
CELL (2014)
Role of LDB1 in the transition from chromatin looping to transcription activation
Ivan Krivega et al.
GENES & DEVELOPMENT (2014)
Dissection of thousands of cell type-specific enhancers identifies dinucleotide repeat motifs as general enhancer features
J. Omar Yanez-Cuna et al.
GENOME RESEARCH (2014)
Genome-wide map of regulatory interactions in the human genome
Nastaran Heidari et al.
GENOME RESEARCH (2014)
High-throughput functional testing of ENCODE segmentation predictions
Jamie C. Kwasnieski et al.
GENOME RESEARCH (2014)
An etiologic regulatory mutation in IRF6 with loss- and gain-of-function effects
Walid D. Fakhouri et al.
HUMAN MOLECULAR GENETICS (2014)
An atlas of active enhancers across human cell types and tissues
Robin Andersson et al.
NATURE (2014)
Enhancer loops appear stable during development and are associated with paused polymerase
Yad Ghavi-Helm et al.
NATURE (2014)
Obesity-associated variants within FTO form long-range functional connections with IRX3
Scott Smemo et al.
NATURE (2014)
Quantitative genome-wide enhancer activity maps for five Drosophila species show functional enhancer conservation and turnover during cis-regulatory evolution
Cosmas D. Arnold et al.
NATURE GENETICS (2014)
Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment
Jim R. Hughes et al.
NATURE GENETICS (2014)
Analysis of nascent RNA identifies a unified architecture of initiation regions at mammalian promoters and enhancers
Leighton J. Core et al.
NATURE GENETICS (2014)
Dynamic regulation of transcriptional states by chromatin and transcription factors
Ty C. Voss et al.
NATURE REVIEWS GENETICS (2014)
Cryptic genetic variation: evolution's hidden substrate
Annalise B. Paaby et al.
NATURE REVIEWS GENETICS (2014)
Transcriptional enhancers: from properties to genome-wide predictions
Daria Shlyueva et al.
NATURE REVIEWS GENETICS (2014)
BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones
Tomohiko Kanno et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)
A novel virus-inducible enhancer of the interferon-β gene with tightly linked promoter and enhancer activities
A. Raja Banerjee et al.
NUCLEIC ACIDS RESEARCH (2014)
Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells
Jessica Zuin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Enhancer RNAs participate in androgen receptor-driven looping that selectively enhances gene activation
Chen-Lin Hsieh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Convergent evolution of complex regulatory landscapes and pleiotropy at Hox loci
Nicolas Lonfat et al.
SCIENCE (2014)
Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression
Benjamin P. Fairfax et al.
SCIENCE (2014)
Nuclear stability and transcriptional directionality separate functionally distinct RNA species
Robin Andersson et al.
NATURE COMMUNICATIONS (2014)
Control of Embryonic Stem Cell Identity by BRD4-Dependent Transcriptional Elongation of Super-Enhancer-Associated Pluripotency Genes
Raffaella Di Micco et al.
CELL REPORTS (2014)
Enhancer variants: evaluating functions in common disease
Olivia Corradin et al.
GENOME MEDICINE (2014)
Methylation QTLs Are Associated with Coordinated Changes in Transcription Factor Binding, Histone Modifications, and Gene Expression Levels
Nicholas E. Banovich et al.
PLOS GENETICS (2014)
Disruption of Autoregulatory Feedback by a Mutation in a Remote, Ultraconserved PAX6 Enhancer Causes Aniridia
Shipra Bhatia et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2013)
Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma
Bjoern Chapuy et al.
CANCER CELL (2013)
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
Lei S. Qi et al.
CELL (2013)
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
Warren A. Whyte et al.
CELL (2013)
Architectural Protein Subclasses Shape 3D Organization of Genomes during Lineage Commitment
Jennifer E. Phillips-Cremins et al.
CELL (2013)
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
Luke A. Gilbert et al.
CELL (2013)
Long-Range Chromatin Contacts in Embryonic Stem Cells Reveal a Role for Pluripotency Factors and Polycomb Proteins in Genome Organization
Matthew Denholtz et al.
CELL STEM CELL (2013)
Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay
Pouya Kheradpour et al.
GENOME RESEARCH (2013)
Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments
Vlad C. Seitan et al.
GENOME RESEARCH (2013)
BLUEPRINT: mapping human blood cell epigenomes
Joost H. A. Martens et al.
HAEMATOLOGICA (2013)
eRNAs Promote Transcription by Establishing Chromatin Accessibility at Defined Genomic Loci
Kambiz Mousavi et al.
MOLECULAR CELL (2013)
Effect of natural genetic variation on enhancer selection and function
S. Heinz et al.
NATURE (2013)
Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation
Wenbo Li et al.
NATURE (2013)
Topology of mammalian developmental enhancers and their regulatory landscapes
Wouter de Laat et al.
NATURE (2013)
The bromodomain protein Brd4 insulates chromatin from DNA damage signalling
Scott R. Floyd et al.
NATURE (2013)
Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription
Michael T. Y. Lam et al.
NATURE (2013)
Activating RNAs associate with Mediator to enhance chromatin architecture and transcription
Fan Lai et al.
NATURE (2013)
A high-resolution map of the three-dimensional chromatin interactome in human cells
Fulai Jin et al.
NATURE (2013)
Massively parallel decoding of mammalian regulatory sequences supports a flexible organizational model
Robin P. Smith et al.
NATURE GENETICS (2013)
Highly parallel assays of tissue-specific enhancers in whole Drosophila embryos
Stephen S. Gisselbrecht et al.
NATURE METHODS (2013)
Transcriptional regulation by Polycomb group proteins
Luciano Di Croce et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)
Swi/Snf chromatin remodeling/tumor suppressor complex establishes nucleosome occupancy at target promoters
Michael Y. Tolstorukov et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Identification of Genetic Variants That Affect Histone Modifications in Human Cells
Graham McVicker et al.
SCIENCE (2013)
Genome-Wide Quantitative Enhancer Activity Maps Identified by STARR-seq
Cosmas D. Arnold et al.
SCIENCE (2013)
Organization of the Mitotic Chromosome
Natalia Naumova et al.
SCIENCE (2013)
An Enhancer Element Harboring Variants Associated with Systemic Lupus Erythematosus Engages the TNFAIP3 Promoter to Influence A20 Expression
Shaofeng Wang et al.
PLOS GENETICS (2013)
Shadow enhancers: Frequently asked questions about distributed cis-regulatory information and enhancer redundancy
Scott Barolo
BIOESSAYS (2012)
A Transcription Factor Collective Defines Cardiac Cell Fate and Reflects Lineage History
Guillaume Junion et al.
CELL (2012)
Controlling Long-Range Genomic Interactions at a Native Locus by Targeted Tethering of a Looping Factor
Wulan Deng et al.
CELL (2012)
Extensive Promoter-Centered Chromatin Interactions Provide a Topological Basis for Transcription Regulation
Guoliang Li et al.
CELL (2012)
Oct4 links multiple epigenetic pathways to the pluripotency network
Junjun Ding et al.
CELL RESEARCH (2012)
A view of nuclear Polycomb bodies
Vincenzo Pirrotta et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2012)
Anterior-posterior differences in HoxD chromatin topology in limb development
Iain Williamson et al.
DEVELOPMENT (2012)
Opposing Functions of the ETS Factor Family Define Shh Spatial Expression in Limb Buds and Underlie Polydactyly
Laura A. Lettice et al.
DEVELOPMENTAL CELL (2012)
Sonic hedgehog acts cell-autonomously on muscle precursor cells to generate limb muscle diversity
Claire Anderson et al.
GENES & DEVELOPMENT (2012)
Regulatory variation in a TBX5 enhancer leads to isolated congenital heart disease
Scott Smemo et al.
HUMAN MOLECULAR GENETICS (2012)
Bromodomain Protein Brd4 Associated with Acetylated Chromatin Is Important for Maintenance of Higher-order Chromatin Structure
Ranran Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Intragenic Enhancers Act as Alternative Promoters
Monika S. Kowalczyk et al.
MOLECULAR CELL (2012)
A functional selection model explains evolutionary robustness despite plasticity in regulatory networks
Naomi Habib et al.
MOLECULAR SYSTEMS BIOLOGY (2012)
DNase I sensitivity QTLs are a major determinant of human expression variation
Jacob F. Degner et al.
NATURE (2012)
The long-range interaction landscape of gene promoters
Amartya Sanyal et al.
NATURE (2012)
A map of the cis-regulatory sequences in the mouse genome
Yin Shen et al.
NATURE (2012)
An integrated encyclopedia of DNA elements in the human genome
Ian Dunham et al.
NATURE (2012)
Topological domains in mammalian genomes identified by analysis of chromatin interactions
Jesse R. Dixon et al.
NATURE (2012)
Spatial partitioning of the regulatory landscape of the X-inactivation centre
Elphege P. Nora et al.
NATURE (2012)
Massively parallel functional dissection of mammalian enhancers in vivo
Rupali P. Patwardhan et al.
NATURE BIOTECHNOLOGY (2012)
Large-scale discovery of enhancers from human heart tissue
Dalit May et al.
NATURE GENETICS (2012)
Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development
Stefan Bonn et al.
NATURE GENETICS (2012)
Iterative correction of Hi-C data reveals hallmarks of chromosome organization
Maxim Imakaev et al.
NATURE METHODS (2012)
Unsupervised pattern discovery in human chromatin structure through genomic segmentation
Michael M. Hoffman et al.
NATURE METHODS (2012)
ChromHMM: automating chromatin-state discovery and characterization
Jason Ernst et al.
NATURE METHODS (2012)
Transcription factors: from enhancer binding to developmental control
Francois Spitz et al.
NATURE REVIEWS GENETICS (2012)
Complexity of chromatin folding is captured by the strings and binders switch model
Mariano Barbieri et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
CTCF/cohesin-mediated DNA looping is required for protocadherin α promoter choice
Ya Guo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Systematic Localization of Common Disease-Associated Variation in Regulatory DNA
Matthew T. Maurano et al.
SCIENCE (2012)
Analysis of variation at transcription factor binding sites in Drosophila and humans
Mikhail Spivakov et al.
GENOME BIOLOGY (2012)
Two Forms of Loops Generate the Chromatin Conformation of the Immunoglobulin Heavy-Chain Gene Locus
Changying Guo et al.
CELL (2011)
Polycomb-Dependent Regulatory Contacts between Distant Hox Loci in Drosophila
Frederic Bantignies et al.
CELL (2011)
A Regulatory Archipelago Controls Hox Genes Transcription in Digits
Thomas Montavon et al.
CELL (2011)
BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
Jake E. Delmore et al.
CELL (2011)
Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation
Qihuang Jin et al.
EMBO JOURNAL (2011)
H3K4 tri-methylation provides an epigenetic signature of active enhancers
Aleksandra Pekowska et al.
EMBO JOURNAL (2011)
Pioneer transcription factors: establishing competence for gene expression
Kenneth S. Zaret et al.
GENES & DEVELOPMENT (2011)
Regulation of nucleosome landscape and transcription factor targeting at tissue-specific enhancers by BRG1
Gangqing Hu et al.
GENOME RESEARCH (2011)
Epigenetic signatures distinguish multiple classes of enhancers with distinct cellular functions
Gabriel E. Zentner et al.
GENOME RESEARCH (2011)
The Histone Chaperone FACT: Structural Insights and Mechanisms for Nucleosome Reorganization
Duane D. Winkler et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
A unique chromatin signature uncovers early developmental enhancers in humans
Alvaro Rada-Iglesias et al.
NATURE (2011)
Mapping and analysis of chromatin state dynamics in nine human cell types
Jason Ernst et al.
NATURE (2011)
Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus
Indra Adrianto et al.
NATURE GENETICS (2011)
Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes
Erik Engelen et al.
NATURE GENETICS (2011)
Multiple enhancers ensure precision of gap gene-expression patterns in the Drosophila embryo
Michael W. Perry et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
The Dynamic Architecture of Hox Gene Clusters
Daan Noordermeer et al.
SCIENCE (2011)
Zelda Binding in the Early Drosophila melanogaster Embryo Marks Regions Subsequently Activated at the Maternal-to-Zygotic Transition
Melissa M. Harrison et al.
PLOS GENETICS (2011)
An Oct4-Centered Protein Interaction Network in Embryonic Stem Cells
Debbie L. C. van den Berg et al.
CELL STEM CELL (2010)
An Expanded Oct4 Interaction Network: Implications for Stem Cell Biology, Development, and Disease
Mercedes Pardo et al.
CELL STEM CELL (2010)
Dissecting the regulatory switches of development: lessons from enhancer evolution in Drosophila
Matthew J. Borok et al.
DEVELOPMENT (2010)
A CTCF-independent role for cohesin in tissue-specific transcription
Dominic Schmidt et al.
GENOME RESEARCH (2010)
Homotypic clusters of transcription factor binding sites are a key component of human promoters and enhancers
Valer Gotea et al.
GENOME RESEARCH (2010)
A Specific Mutation in the Distant Sonic Hedgehog (SHH) Cis-Regulator (ZRS) Causes Werner Mesomelic Syndrome (WMS) While Complete ZRS Duplications Underlie Haas Type Polysyndactyly and Preaxial Polydactyly (PPD) With or Without Triphalangeal Thumb
Dagmar Wieczorek et al.
HUMAN MUTATION (2010)
A Model for all Genomes: The Role of Transcription Factories
Peter R. Cook
JOURNAL OF MOLECULAR BIOLOGY (2010)
Dynamic CRM occupancy reflects a temporal map of developmental progression
Bartek Wilczynski et al.
MOLECULAR SYSTEMS BIOLOGY (2010)
Widespread transcription at neuronal activity-regulated enhancers
Tae-Kyung Kim et al.
NATURE (2010)
Mediator and cohesin connect gene expression and chromatin architecture
Michael H. Kagey et al.
NATURE (2010)
The NIH Roadmap Epigenomics Mapping Consortium
Bradley E. Bernstein et al.
NATURE BIOTECHNOLOGY (2010)
Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells
Stefan Schoenfelder et al.
NATURE GENETICS (2010)
ChIP-Seq identification of weakly conserved heart enhancers
Matthew J. Blow et al.
NATURE GENETICS (2010)
Histone H3K27ac separates active from poised enhancers and predicts developmental state
Menno P. Creyghton et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Five-Vertebrate ChIP-seq Reveals the Evolutionary Dynamics of Transcription Factor Binding
Dominic Schmidt et al.
SCIENCE (2010)
Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE
Sushmita Roy et al.
SCIENCE (2010)
Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project
Mark B. Gerstein et al.
SCIENCE (2010)
Transcription factor binding variation in the evolution of gene regulation
Robin D. Dowell
TRENDS IN GENETICS (2010)
Chromatin Higher-order Structure and Dynamics
Christopher L. Woodcock et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
A Large Fraction of Extragenic RNA Pol II Transcription Sites Overlap Enhancers
Francesca De Santa et al.
PLOS BIOLOGY (2010)
Chromosomal Dynamics at the Shh Locus: Limb Bud-Specific Differential Regulation of Competence and Active Transcription
Takanori Amano et al.
DEVELOPMENTAL CELL (2009)
An oestrogen-receptor-α-bound human chromatin interactome
Melissa J. Fullwood et al.
NATURE (2009)
ChIP-seq accurately predicts tissue-specific activity of enhancers
Axel Visel et al.
NATURE (2009)
Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome
Erez Lieberman-Aiden et al.
SCIENCE (2009)
Sister Chromatid Cohesion: A Simple Concept with a Complex Reality
Itay Onn et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY (2008)
Cohesins functionally associate with CTCF on mammalian chromosome arms
Vania Parelho et al.
CELL (2008)
Virus infection induces NF-κB-dependent interchromosomal associations mediating monoallelic IFN-β gene expression
Effie Apostolou et al.
CELL (2008)
Cryptic genetic variation
Greg Gibson et al.
CURRENT BIOLOGY (2008)
The words of the regulatory code are arranged in a variable manner in highly conserved enhancers
Sepand Rastegar et al.
DEVELOPMENTAL BIOLOGY (2008)
The zinc-finger protein Zelda is a key activator of the early zygotic genome in Drosophila
Hsiao-Lan Liang et al.
NATURE (2008)
Cohesin mediates transcriptional insulation by CCCTC-binding factor
Kerstin S. Wendt et al.
NATURE (2008)
Spatial configuration of the chicken α-globin gene domain:: immature and active chromatin hubs
Alexey A. Gavrilov et al.
NUCLEIC ACIDS RESEARCH (2008)
CTCF-dependent enhancer-blocking by alternative chromatin loop formation
Chunhui Hou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
CTCF physically links cohesin to chromatin
Eric D. Rubio et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Shadow enhancers as a source of evolutionary novelty
Joung-Woo Hong et al.
SCIENCE (2008)
Sepsid even-skipped Enhancers Are Functionally Conserved in Drosophila Despite Lack of Sequence Conservation
Emily E. Hare et al.
PLOS GENETICS (2008)
A positive role for NLI/Ldb1 in long-range β-globin locus control region function
Sang-Hyun Song et al.
MOLECULAR CELL (2007)
RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo
Julia Zeitlinger et al.
NATURE GENETICS (2007)
Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription
Dwayne A. Bisgrovet et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
An atomic model of the interferon-β enhanceosome
Daniel Panne et al.
CELL (2007)
Transgenic analysis of Hoxd gene regulation during digit development
Federico Gonzalez et al.
DEVELOPMENTAL BIOLOGY (2007)
High-resolution profiling of histone methylations in the human genome
Artern Barski et al.
CELL (2007)
Systematic discovery of regulatory motifs in conserved regions of the human genome, including thousands of CTCF insulator sites
Xiaohui Xie et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome
Tae Hoon Kim et al.
CELL (2007)
Transcriptional noise and the fidelity of initiation by RNA polymerase II
Kevin Struhl
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
Epigenetic signatures of stem-cell identity
Mikhail Spivakov et al.
NATURE REVIEWS GENETICS (2007)
A genome scale location analysis of human Staf/ZNF143-binding sites suggests a widespread role for human Staf/ZNF143 in mammalian promoters
Evelyne Myslinski et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions
Zhihu Zhao et al.
NATURE GENETICS (2006)
Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C)
Marieke Simonis et al.
NATURE GENETICS (2006)
Chromosome Conformation Capture Carbon Copy (5C): A massively parallel solution for mapping interactions between genomic elements
Josee Dostie et al.
GENOME RESEARCH (2006)
CTCF mediates long-range chromatin looping and local histone modification in the β-globin locus
Erik Splinter et al.
GENES & DEVELOPMENT (2006)
Core transcriptional regulatory circuitry in human embryonic stem cells
LA Boyer et al.
CELL (2005)
Transcriptional enhancers: Intelligent enhanceosomes or flexible billboards?
DN Arnosti et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2005)
Proximity among Distant Regulatory Elements at the β-Globin Locus Requires GATA-1 and FOG-1
CR Vakoc et al.
MOLECULAR CELL (2005)
Multiple interactions between regulatory regions are required to stabilize an active chromatin hub
GP Patrinos et al.
GENES & DEVELOPMENT (2004)
The active spatial organization of the β-globin locus requires the transcription factor EKLF
R Drissen et al.
GENES & DEVELOPMENT (2004)
Cap analysis gene expression for high-throughput analysis of transcriptional starting point and identification of promoter usage
T Shiraki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Estrogen receptor-α directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter
R Métivier et al.
CELL (2003)
The β-globin nuclear compartment in development and erythroid differentiation
RJ Palstra et al.
NATURE GENETICS (2003)
A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly
LA Lettice et al.
HUMAN MOLECULAR GENETICS (2003)
Information display by transcriptional enhancers
MM Kulkarni et al.
DEVELOPMENT (2003)
Looping and interaction between hypersensitive sites in the active β-globin locus
B Tolhuis et al.
MOLECULAR CELL (2002)
Long-range chromatin regulatory interactions in vivo
D Carter et al.
NATURE GENETICS (2002)
Insulators: many functions, many mechanisms
AG West et al.
GENES & DEVELOPMENT (2002)
Enhancer-promoter specificity mediated by DPE or TATA core promoter motifs
JEF Butler et al.
GENES & DEVELOPMENT (2001)
CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease
R Ohlsson et al.
TRENDS IN GENETICS (2001)
Transcriptional regulation at a distance in bacteria
H Xu et al.
CURRENT OPINION IN MICROBIOLOGY (2001)
Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive
C Kanduri et al.
CURRENT BIOLOGY (2000)
CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
AT Hark et al.
NATURE (2000)
Structural and functional conservation at the boundaries of the chicken β-globin domain
N Saitoh et al.
EMBO JOURNAL (2000)
Looping, linking, and chromatin activity:: New insights into β-globin locus regulation
JD Engel et al.
CELL (2000)
β-globin gene switching and DNase I sensitivity of the endogenous β-globin locus in mice do not require the locus control region
MA Bender et al.
MOLECULAR CELL (2000)