Neutralizing shapeshifting pericytes enhances glioblastoma therapeutic efficacy

Article Oncology

Upregulated functional gene expression programmes in tumour pericytes mark progression in patients with low-grade glioma

Clara Oudenaarden et al.

Summary: The study utilized a comprehensive computational biology approach to annotate pericyte marker genes in the GBM vasculature, identifying distinct vascular- and immune-related gene expression programs in tumor pericytes that may be associated with GBM characteristics and patient survival. The findings suggest the functional importance of tumor pericytes in low-grade glioma and could potentially be a starting point for precision targeting of pericytes.

MOLECULAR ONCOLOGY (2022)

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Article Cell Biology

Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling

Xiao-Ning Zhang et al.

Summary: The study reveals the role of pericytes in potentiating DDR signaling in GBM cells, and suggests that targeting CCL5-CCR5 signaling could be an effective therapeutic strategy to improve chemotherapeutic efficacy against GBM.

CELL RESEARCH (2021)

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Review Pharmacology & Pharmacy

Modulation of the chemokine/chemokine receptor axis as a novel approach for glioma therapy

Gregory P. Takacs et al.

Summary: Chemokines play a crucial role in regulating cell migration, particularly in the immune system and cancer. Gliomas, as common and challenging primary tumors of the central nervous system, could potentially benefit from immunotherapy approaches. Manipulating chemokine/chemokine receptor systems may offer therapeutic advantages in treating malignant gliomas and other cancers.

PHARMACOLOGY & THERAPEUTICS (2021)

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Article Oncology