Journal
CELL RESEARCH
Volume 31, Issue 8, Pages 829-831Publisher
SPRINGERNATURE
DOI: 10.1038/s41422-021-00518-5
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Funding
- French government, through the Agence Nationale de la Recherche [ANR-15-IDEX-01, ANR-11-LABX-0028-01, ANR-16-CE12-0020, ANR-19-CE12-0032]
- Fondation pour la Recherche Medicale (FRM) [DEQ20180339170]
- Inserm (GOLD cross-cutting programme on genomic variability)
- CNRS [GDR 3546]
- University Hospital Federation (FHU) OncoAge
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Retrotransposons, abundant mobile genetic elements in mammalian genomes, can interfere with genomic processes such as gene transcription. A study shows that segments of nascent RNAs containing retrotransposons are enriched in N-6-methyladenosine and act as transcriptional roadblocks, but cellular proteins SAFB/SAFB2 can alleviate this effect.
Retrotransposons are highly abundant mobile genetic elements in mammalian genomes and can interfere with many genomic processes, particularly the transcription of genes. A study by Xiong et al. reveals that segments of nascent RNAs containing retrotransposons are enriched in N-6-methyladenosine and act as transcriptional roadblocks for elongating RNA polymerase II, but that cellular proteins capable of binding to these RNAs, SAFB/SAFB2, can mitigate this effect.
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