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T-cell infiltration, contribution and regulation in the central nervous system post-traumatic injury

Journal

CELL PROLIFERATION
Volume 54, Issue 8, Pages -

Publisher

WILEY
DOI: 10.1111/cpr.13092

Keywords

central nervous system; clinical intervention; contribution; post-traumatic injury; T cell

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Funding

  1. National Natural Science Foundation of China [81972138, 81572229]

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T cells play a significant role in the repair process and immune response in the central nervous system post-traumatic injury, with both beneficial and harmful effects. The advancement of new techniques has made research focusing on T cells a valuable direction for future therapy of traumatic CNS injury.
T cells participate in the repair process and immune response in the CNS post-traumatic injury and play both a beneficial and harmful role. Together with nerve cells and other immune cells, they form a microenvironment in the CNS post-traumatic injury. The repair of traumatic CNS injury is a long-term process. T cells contribute to the repair of the injury site to influence the recovery. Recently, with the advance of new techniques, such as mass spectrometry-based flow cytometry, modern live-cell imaging, etc, research focusing on T cells is becoming one of the valuable directions for the future therapy of traumatic CNS injury. In this review, we summarized the infiltration, contribution and regulation of T cells in post-traumatic injury, discussed the clinical significance and predicted the future research direction.

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