Journal
CELL METABOLISM
Volume 33, Issue 9, Pages 1719-1720Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2021.08.010
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The study identified a selective requirement for pyruvate dehydrogenase (PDH) activity in T cells and T cell leukemia, but not in hematopoietic stem cells (HSCs) or myeloid leukemia, supporting the idea that cell lineage plays a key role in cancer cell metabolism.
Supporting the notion that cell lineage is a key determinant of cancer cell metabolism, Jun et al. (2021) identify a selective requirement for pyruvate dehydrogenase (PDH) activity in T cells and T cell leukemia, but not hematopoietic stem cells (HSCs) or myeloid leukemia, in this issue of Cell Metabolism.
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