Journal
CELL METABOLISM
Volume 33, Issue 6, Pages 1073-1075Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2021.05.004
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Funding
- FNRS (Projet de Recherche PDRconvention: FNRS) [T.0030.21P]
- Agence Nationale de la Recherche (ANR) [ANR-18-CE14-0007-01]
- INSERM (International Research Project, IRP)
- FNRS (Projet de Recherche PDRconvention: FRFSWELBIO) [WELBIOCR2019C02R]
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The study identified a novel protein (P9) secreted by Akkermansia muciniphila that stimulates GLP-1 secretion, providing new insights for treating metabolic diseases.
Akkermansia muciniphila is a gut commensal known to improve host metabolism. The outer membrane protein Amuc_1100 has been shown to partially replicate these beneficial effects. Here, Yoon et al. (2021) have identified a novel protein (P9) secreted by A. muciniphila that stimulates GLP-1 secretion, thereby adding new insight to the biomolecule era to treat metabolic diseases.
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