Mitochondrial quality control: Just walk away

Review Cell & Tissue Engineering

Mitochondria as Signaling Organelles Control Mammalian Stem Cell Fate

Ram Prosad Chakrabarty et al.

Summary: Mitochondrial metabolism plays a crucial role in determining stem cell fate and function, beyond its traditional roles in ATP production and support for stem cell survival and growth. This review focuses on key conceptual ideas regarding how mitochondria control mammalian stem cell fate and function through mechanisms such as reactive oxygen species generation and TCA cycle metabolite production.

CELL STEM CELL (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Mitocytosis, a migrasome-mediated mitochondrial quality-control process

Haifeng Jiao et al.

Summary: Mitocytosis is a migrasome-mediated mitochondrial quality-control process that helps maintain mitochondrial quality in migrating cells. The process involves positioning damaged mitochondria at the cell periphery, which avoids binding to inward motor proteins. Enhanced mitocytosis protects cells from mitochondrial stressor-induced loss of mitochondrial membrane potential and mitochondrial respiration, while blocking mitocytosis causes loss of these functions under normal conditions. Physiologically, mitocytosis is required for maintaining mitochondrial membrane potential and viability in neutrophils in vivo.

CELL (2021)

Add to Collection

Review Biochemistry & Molecular Biology