Journal
CELL METABOLISM
Volume 33, Issue 8, Pages 1516-1518Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2021.07.013
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Funding
- Pew Biomedical Scholarship
- NIH Director's New Innovator Award [DP2AG067492]
- Agilent Early Career Professor Award
- IDSA Foundation
- Thyssen Foundation
- Penn-CHOP Microbiome Program
- Penn Institute for Immunology
- Penn Center for Molecular Studies in Digestive and Liver Diseases [P30DK050306]
- Penn Diabetes Research Center [P30DK019525]
- Penn Institute on Aging
- Medical Scientist Training Program (MSTP) [T32 GM07170]
- Penn Skin Biology and Diseases Resource-based Center [P30AR069589]
- Edward Mallinckrodt, Jr. Foundation
- [T32 AI141393]
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The study found that changes in the intestinal microbiome and metabolome induced by a high-fat diet facilitate the development of antibiotic tolerance by bacterial pathogens.
Antibiotic tolerance enables microorganisms to survive the exposure to antibiotics and serves as a precursor to antibiotic resistance. In a recent issue of Nature Microbiology, Liu et al. (2021) describe that high-fat-diet induced changes in the intestinal microbiome and metabolome facilitate the development of antibiotic tolerance by bacterial pathogens.
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