Journal
CELL HOST & MICROBE
Volume 29, Issue 7, Pages 1137-+Publisher
CELL PRESS
DOI: 10.1016/j.chom.2021.06.001
Keywords
-
Categories
Funding
- Ministere de l'Economie et de l'Innovation du Quebec, Programme de Soutien aux Organismes de Recherche et d'Innovation
- Fondation du CHUM
- CIHR foundation grant [352417]
- Exceptional Fund COVID-19 from the Canada Foundation for Innovation (CFI) [41027]
- Sentinelle COVID Quebec network
- Fonds de Recherche du Quebec Sante (FRQS)
- Genome Canada-Genome Quebec
- NIH [AI144462 CHAVD, R01 AI122953-05]
- Canada Research Chair on Retroviral Entry [RCHS0235 950-232424]
- FRQS
- CIHR fellowships
- MITACS Acceleration postdoctoral fellowship
Ask authors/readers for more resources
A single dose of the BNT162b2 mRNA vaccine can be up to 90% effective, with boosted humoral and T cell responses in previously infected individuals. Therefore, spacing doses may help vaccinate more people in conditions of limited vaccine supply.
While the standard regimen of the BNT162b2 mRNA vaccine for SARS-CoV-2 includes two doses administered 3 weeks apart, some public health authorities are spacing these doses, raising concerns about efficacy. However, data indicate that a single dose can be up to 90% effective starting 14 days post-administration. To assess the mechanisms contributing to protection, we analyzed humoral and T cell responses three weeks after a single BNT162b2 dose. We observed weak neutralizing activity elicited in SARS-CoV-2 naive individuals but strong anti-receptor binding domain and spike antibodies with Fc-mediated effector functions and cellular CD4(+) T cell responses. In previously infected individuals, a single dose boosted all humoral and T cell responses, with strong correlations between T helper and antibody immunity. Our results highlight the potential role of Fc-mediated effector functions and T cell responses in vaccine efficacy. They also provide support for spacing doses to vaccinate more individuals in conditions of vaccine scarcity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available