Journal
CELL CALCIUM
Volume 96, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2021.102372
Keywords
Neuronal calcium homeostasis; Orai channels; Spine calcium signaling; Synaptic plasticity
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Funding
- Deutsche Forschungsgemeinschaft [SFB 870]
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This study explores the critical role of Orai1 channels in hippocampal neurons, which contribute to the Ca2+ signal and synaptic plasticity associated with learning and memory. The findings contrast with previous reports emphasizing the roles of Orai2 channels and overlooking the functions of Orai1 channels in these neurons.
Orai1 channels were reported as critical contributors to the Ca2+ signal in hippocampal neurons underlying synaptic plasticity associated with learning and memory. We discuss the results in view of conflicting other reports that stressed the roles of Orai2 channels but failed to detect functions of Orai1 channels in these neurons.
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