Organs-on-a-chip models for biological research

We explore the utility of bioengineered human tissues-individually or connected into physiological units-for biological research. While much smaller and simpler than their native counterparts, these tissues are complex enough to approximate distinct tissue phenotypes: molecular, structural, and functional. Unlike organoids, which form spontaneously and recapitulate development, organs-on-a-chip'' are engineered to display some specific functions of whole organs. Looking back, we discuss the key developments of this emerging technology. Thinking forward, we focus on the challenges faced to fully establish, validate, and utilize the fidelity of these models for biological research.

Automated summary

Bioengineered human tissues exhibit enough complexity to mimic native tissues, and organs-on-a-chip are better at displaying specific organ functions compared to organoids. The key to this emerging technology lies in establishing, validating, and fully utilizing the fidelity of these models.