4.3 Editorial Material

A novel coronavirus meets the cardiovascular system: Society for Cardiovascular Pathology Symposium 2021

Related references

Note: Only part of the references are listed.
Review Peripheral Vascular Disease

Covid-19 and the cardiovascular system: a comprehensive review

Rafael Bellotti Azevedo et al.

Summary: In patients infected with COVID-19, cardiac injury is associated with higher morbimortality, and is characterized by inflammation response and multiple organ dysfunction syndrome caused by the virus. Hypertension and diabetes are common comorbidities, while cardiac injury is significantly related to inflammation biomarkers, hyperferritinemia, and leukocytosis.

JOURNAL OF HUMAN HYPERTENSION (2021)

Review Pathology

Immunopathology of Hyperinflammation in COVID-19

Joshua N. Gustine et al.

Summary: The rapid spread of COVID-19 has led to an unprecedented global public health crisis with recent studies suggesting that the hyperinflammatory syndrome induced by SARS-CoV-2 is a contributing factor to disease severity and mortality. Pathophysiological research shows that the hyperinflammatory syndrome in severe COVID-19 results from a dysregulated innate immune response. Current potential therapeutic approaches are being investigated to modulate the immune response and mitigate lung injury in severe COVID-19.

AMERICAN JOURNAL OF PATHOLOGY (2021)

Review Urology & Nephrology

Immunity, endothelial injury and complement-induced coagulopathy in COVID-19

Luca Perico et al.

Summary: This review provides insights into the pathogenic mechanisms and clinical manifestations of COVID-19, highlighting the critical role of the immunological hyper-response induced by SARS-CoV-2 infection. The authors emphasize the importance of early diagnosis and intervention in controlling disease progression.

NATURE REVIEWS NEPHROLOGY (2021)

Article Cardiac & Cardiovascular Systems

COVID-19-A vascular disease

Hasan K. Siddiqi et al.

Summary: SARS-CoV-2 causes multi-system dysfunction, with emerging evidence indicating that endothelial injury plays a crucial role. Therapies targeting vascular system dysfunction may be important in treating SARS-CoV-2 infection and its long-lasting effects.

TRENDS IN CARDIOVASCULAR MEDICINE (2021)

Article Medical Laboratory Technology

A Postmortem Portrait of the Coronavirus Disease 2019 (COVID-19) Pandemic

Jody E. Hooper et al.

Summary: This study presents comprehensive data from 135 autopsies of COVID-19-positive decedents, showing that patients had an average of 8.89 pathologic conditions, consisting of preexisting chronic diseases and acute conditions acquired during hospitalization. Most patients had multiple preexisting conditions, with clinical conditions during terminal hospitalization mainly involving acute organ failure and impaired coagulation.

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE (2021)

Article Cardiac & Cardiovascular Systems

Microthrombi as a Major Cause of Cardiac Injury in COVID-19 A Pathologic Study

Dario Pellegrini et al.

Summary: Analysis of heart tissue from 40 deceased COVID-19 patients revealed that microthrombi were the most common pathological cause of myocyte necrosis. Female patients with chronic kidney disease and shorter symptom onset to admission time were more likely to have myocyte necrosis. Tailored antithrombotic strategies may be useful to counteract the cardiac effects of COVID-19 infection.

CIRCULATION (2021)

Review Cardiac & Cardiovascular Systems

Pathological Evidence for SARS-CoV-2 as a Cause of Myocarditis JACC Review Topic of the Week

Rika Kawakami et al.

Summary: Myocarditis is rare in COVID-19 patients, with virus detected in the heart in only a few cases. Myocarditis may be caused by macrophages and T cells, but it does not represent clinically relevant myocarditis.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

Review Urology & Nephrology

Best practices for correctly identifying coronavirus by transmission electron microscopy

Hannah A. Bullock et al.

Summary: This guidance provides clear and concise strategies for identifying coronaviruses using transmission electron microscopy of ultrathin sections of tissues or infected tissue cultures. It includes descriptions of virus morphology and cell organelles that can resemble viruses, as well as discussions on biochemical testing and caveats. The numerous references provided can be used for documentation and further study.

KIDNEY INTERNATIONAL (2021)

Review Virology

Endothelium Infection and Dysregulation by SARS-CoV-2: Evidence and Caveats in COVID-19

Isabelle Bernard et al.

Summary: The ongoing COVID-19 pandemic poses a persistent threat to global public health, with extrapulmonary manifestations including gastrointestinal, cardiovascular, renal, and neurological diseases. Recent studies suggest that dysfunction of the endothelium during COVID-19 may exacerbate deleterious events through inflammatory and microvascular thrombotic processes, potentially due to SARS-CoV-2 infecting endothelial cells via ACE2 receptor binding.

VIRUSES-BASEL (2021)

Article Cardiac & Cardiovascular Systems

Fatal Takotsubo syndrome in critical COVID-19 related pneumonia

Luca Titi et al.

Summary: COVID-19 can lead to cardiac damage, with rare occurrences of Takotsubo syndrome in patients. This condition can cause significant myocardial injury and pathological changes, often leading to patient deterioration and eventual death.

CARDIOVASCULAR PATHOLOGY (2021)

Article Immunology

Evidence of Severe Acute Respiratory Syndrome Coronavirus 2 Replication and Tropism in the Lungs, Airways, and Vascular Endothelium of Patients With Fatal Coronavirus Disease 2019: An Autopsy Case Series

Julu Bhatnagar et al.

Summary: This study identified cellular targets of SARS-CoV-2 tropism and replication in various tissues, showing direct infection in the lungs and airways. The research provides important insights into COVID-19 pathogenesis and mechanisms of severe outcomes.

JOURNAL OF INFECTIOUS DISEASES (2021)

Article Pathology

Factors associated with myocardial SARS-CoV-2 infection, myocarditis, and cardiac inflammation in patients with COVID-19

Mayara Bearse et al.

Summary: COVID-19 is associated with cardiac injury and dysfunction, with cardiac infection by SARS-CoV-2 being common among patients who have died from the disease but often with only rare infected cells. Cardiac infection by SARS-CoV-2 is linked to more cardiac inflammation and electrocardiographic changes. Nonbiologic immunosuppression is associated with lower incidences of myocarditis and cardiac infection by SARS-CoV-2.

MODERN PATHOLOGY (2021)

Editorial Material Medicine, General & Internal

On the Shoulders of Giants - From Jenner's Cowpox to mRNA Covid Vaccines

Angela Desmond et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Cardiac & Cardiovascular Systems

SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis

Adam L. Bailey et al.

Summary: The study provides evidence that cardiomyocytes are infected in patients with COVID-19 myocarditis, leading to severe acute respiratory syndrome coronavirus 2 infection that results in various detrimental effects, including contractile deficits and cell death.

JACC-BASIC TO TRANSLATIONAL SCIENCE (2021)

Article Immunology

Difficulties in Differentiating Coronaviruses from Subcellular Structures in Human Tissues by Electron Microscopy

Hannah A. Bullock et al.

Summary: Efforts to combat the COVID-19 pandemic have highlighted the use of transmission electron microscopy for identifying coronavirus in tissues. Some investigators inaccurately reported subcellular structures as coronavirus particles, while in fact, there are distinct morphological features that differentiate coronavirus from subcellular structures, such as particle size range and the appearance of the nucleocapsid.

EMERGING INFECTIOUS DISEASES (2021)

Article Cardiac & Cardiovascular Systems

Myocardial localization of coronavirus in COVID-19 cardiogenic shock

Guido Tavazzi et al.

EUROPEAN JOURNAL OF HEART FAILURE (2020)

Review Cardiac & Cardiovascular Systems

Recent Advances in T1 and T2 Mapping in the Assessment of Fulminant Myocarditis by Cardiac Magnetic Resonance

P. Wheen et al.

CURRENT CARDIOLOGY REPORTS (2020)

Article Critical Care Medicine

Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans

Sharon E. Fox et al.

LANCET RESPIRATORY MEDICINE (2020)

Article Medicine, General & Internal

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

Maximilian Ackermann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Letter Medicine, General & Internal

Cardiac Endotheliitis and Multisystem Inflammatory Syndrome After COVID-19

Sharon E. Fox et al.

ANNALS OF INTERNAL MEDICINE (2020)

Letter Cardiac & Cardiovascular Systems

Unexpected Features of Cardiac Pathology in COVID-19 Infection

Sharon E. Fox et al.

CIRCULATION (2020)

Editorial Material Hematology

Endothelial cells orchestrate COVID-19 coagulopathy Comment

Jamie M. O'Sullivan et al.

LANCET HAEMATOLOGY (2020)

Review Medicine, General & Internal

Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19) A Review

W. Joost Wiersinga et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Review Cardiac & Cardiovascular Systems

COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives

Masataka Nishiga et al.

NATURE REVIEWS CARDIOLOGY (2020)

Editorial Material Cardiac & Cardiovascular Systems

Severe COVID-19 Is a Microvascular Disease

Charles J. Lowenstein et al.

CIRCULATION (2020)

Article Cardiac & Cardiovascular Systems

Pathological features of COVID-19-associated myocardial injury: a multicentre cardiovascular pathology study

Cristina Basso et al.

EUROPEAN HEART JOURNAL (2020)

Editorial Material Cardiac & Cardiovascular Systems

COVID-19 is, in the end, an endothelial disease

Peter Libby et al.

EUROPEAN HEART JOURNAL (2020)

Letter Hematology

Severe COVID-19 infection associated with endothelial activation

Robert Escher et al.

THROMBOSIS RESEARCH (2020)

Review Radiology, Nuclear Medicine & Medical Imaging

State of the art: Evaluation and prognostication of myocarditis using cardiac MRI

Michael P. Gannon et al.

JOURNAL OF MAGNETIC RESONANCE IMAGING (2019)

Review Cardiac & Cardiovascular Systems

Diagnostic Accuracy of Cardiovascular Magnetic Resonance in Acute Myocarditis A Systematic Review and Meta-Analysis

Christos P. Kotanidis et al.

JACC-CARDIOVASCULAR IMAGING (2018)

Review Cardiac & Cardiovascular Systems

Cardiovascular Magnetic Resonance in Nonischemic Myocardial Inflammation Expert Recommendations

Vanessa M. Ferreira et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

Article Radiology, Nuclear Medicine & Medical Imaging

Initial Experience With Simultaneous 18F-FDG PET/MRI in the Evaluation of Cardiac Sarcoidosis and Myocarditis

Kate Hanneman et al.

CLINICAL NUCLEAR MEDICINE (2017)

Article Cardiac & Cardiovascular Systems

Cardiovascular Magnetic Resonance in Myocarditis: A JACC White Paper

Matthias G. Friedrich et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2009)