4.7 Article

Proteomic mechanistic profile of patients with diabetes at risk of developing heart failure: insights from the HOMAGE trial

Related references

Note: Only part of the references are listed.
Article Cardiac & Cardiovascular Systems

Proteomic and Mechanistic Analysis of Spironolactone in Patients at Risk for HF

Joao Pedro Ferreira et al.

Summary: This study found that spironolactone exerts cardiovascular protective effects by reducing fibrosis, inflammation, thrombosis, congestion, and improving vascular function through multiple pathways, potentially slowing the progression toward heart failure.

JACC-HEART FAILURE (2021)

Article Cardiac & Cardiovascular Systems

The effect of spironolactone on cardiovascular function and markers of fibrosis in people at increased risk of developing heart failure: the heart 'OMics' in AGEing (HOMAGE) randomized clinical trial

John G. F. Cleland et al.

Summary: The study showed that spironolactone had an impact on collagen synthesis and metabolism in high-risk individuals for heart failure, without interaction with serum galectin-3. Spironolactone treatment led to changes in type-I collagen metabolism.

EUROPEAN HEART JOURNAL (2021)

Article Cardiac & Cardiovascular Systems

The role of cathepsin D in the pathophysiology of heart failure and its potentially beneficial properties: a translational approach

Martijn F. Hoes et al.

EUROPEAN JOURNAL OF HEART FAILURE (2020)

Article Multidisciplinary Sciences

GDF15 mediates the effects of metformin on body weight and energy balance

Anthony P. Coll et al.

NATURE (2020)

Article Cardiac & Cardiovascular Systems

Distinct Pathological Pathways in Patients With Heart Failure and Diabetes

Jasper Tromp et al.

JACC-HEART FAILURE (2020)

Article Biochemistry & Molecular Biology

IL1R1 is required for celastrol's leptin-sensitization and antiobesity effects

Xudong Feng et al.

NATURE MEDICINE (2019)

Article Endocrinology & Metabolism

Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss

Emily A. Day et al.

NATURE METABOLISM (2019)

Article Cardiac & Cardiovascular Systems

Identifying Pathophysiological Mechanisms in Heart Failure With Reduced Versus Preserved Ejection Fraction

Jasper Tromp et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

Article Biochemistry & Molecular Biology

Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction

Junli Liu et al.

Article Cardiac & Cardiovascular Systems

Usefulness of Growth Differentiation Factor-15 Levels to Predict Diabetic Cardiomyopathy in Asymptomatic Patients With Type 2 Diabetes Mellitus

Alberto Dominguez-Rodriguez et al.

AMERICAN JOURNAL OF CARDIOLOGY (2014)

Article Cell Biology

Adipocyte Inflammation Is Essential for Healthy Adipose Tissue Expansion and Remodeling

Ingrid Wernstedt Asterholm et al.

CELL METABOLISM (2014)

Article Endocrinology & Metabolism

Lysosomal Cathepsin D contributes to cell death during adipocyte hypertrophy

Akiko Eguchi et al.

ADIPOCYTE (2013)

Article Cardiac & Cardiovascular Systems

Effect of eplerenone versus spironolactone on cortisol and hemoglobin A1c levels in patients with chronic heart failure

Masayuki Yamaji et al.

AMERICAN HEART JOURNAL (2010)

Article Cardiac & Cardiovascular Systems

The effect of diabetes on outcomes of patients with advanced-heart failure in the BEST trial

M Domanski et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2003)