Journal
CARBOHYDRATE POLYMERS
Volume 275, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.118691
Keywords
Sea cucumber; Fucosylated chondroitin sulfate; Metabolic syndrome; Gut microbiota; Structure-activity relationship
Categories
Funding
- Guangdong Province Zhujiang Talent Program [2019ZT08H476]
- Shenzhen Science and Technology Program [KQTD20180412181334790]
- Innovation Team Project of Universities in Guangdong Province [2020KCXTD023]
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Fucosylated chondroitin sulfates (FCS) are a type of sulfated polysaccharide found exclusively in the body wall of sea cucumber, with potential benefits in preventing metabolic syndromes and other diseases. Studies suggest that the positive effects of FCS may be achieved by modulating gut microbiota composition.
Fucosylated chondroitin sulfates (FCS) are a sulfated polysaccharide exclusively existing in the body wall of sea cucumber. FCS possesses a mammalian chondroitin sulfate like backbone, namely repeating disaccharides units composed of GlcA and GalNAc, with fucosyl branches linked to GlcA and/or GalNAc residues. It is found that FCS can prevent unhealthy dietary pattern-induced metabolic syndromes, including insulin resistance and B-cell function improvement, anti-inflammation, anti-hyperlipidemia, and anti-adipogenesis. Further studies show that those activities of FCS might be achieved through positively modulating gut microbiota composition. Besides, FCS also show therapeutic efficacy in cancer, HIV infection, and side effects of cyclophosphamide. Furthermore, bioactivities of FCS are closely affected by their molecular weights, sulfation pattern of the fucosyl branches, and chain conformations. This review summarizes the recent 20 years studies to provide references for the future studies and applications of FCS in functional foods or drugs.
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