Journal
CARBOHYDRATE POLYMERS
Volume 261, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.117833
Keywords
Sesbania cannabina; Galactomannan; Selenylation; Anti-oxidative capacity; Immunomodulatory activity
Categories
Funding
- National Key R&D Program of China [2016YFD0600803]
- Priority Academic Program Development of Jiangsu Higher Education Institution (PAPD)
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Seleno-galactomannans (SeGMs) prepared from galactomannan showed stronger protective effect against oxidative damage, but selenylation modification did not affect their immunomodulatory activity.
Seleno-polysaccharides have become a major topic for research owing to their high anti-oxidative capacity and immune-enhancing activities. In this study, galactomannan (GM) was isolated from Sesbania cannabina, and next modified using HNO3?Na2SeO3 method to obtain six varieties of seleno-galactomannans (SeGMs). FT-IR and GPC results showed the changes in chemical structure of SeGMs, indicating successful combination of selenium and GM. By measuring superoxide dismutase and malondialdehyde, the SeGMs showed a stronger protective effect against H2O2-induced oxidative damage in vitro than unmodified GM using macrophage RAW264.7 cell as a model, and the effect of SeGMs-14 was prominent. However, the selenylation modification did not show any obvious effect on the immunomodulatory activity of GM, as determined by the index of tumor necrosis factor-?, interleukin-6, and interleukin-113. Overall, the prepared SeGMs from galactomannan could potentially serve as a dietary supplement of Se or an organic antioxidant.
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