Journal
CARBOHYDRATE POLYMERS
Volume 261, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.117874
Keywords
Aloe polysaccharides; Ultrasound extraction; Gut microbiota; In-depth bioinformatics analysis
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Funding
- National Key Research and Development Program of China [2019YFC1606000, 2020YFC1606800, 2018YFC1604202]
- Development Program of Jiangsu Province [BE2019362]
- National Firstclass Discipline Program of Food Science and Technology [JUFSTR20180509, BWS12B142]
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The study revealed that APs can promote fructose and mannose metabolism by boosting SCFAs-producing Parabacteria and Clostridium, demonstrating prebiotic effects on gut microbiota.
Despite the well-known health benefits of aloe polysaccharide (APs), little is known about how APs modulate the gut microbiota and the relationship between microbiota and SCFAs. Here, APs was extracted by ultrasound extraction. FT-IR and glycosidic linkage type analysis showed that a major part of APs consisted of ? 4)-?-Manp(1 ? residues with acetyl groups. APs supplementation to mice prominently boosted SCFAs-producing Bacteroides and Parabacteria in the feces. On the other hand, it decreased the abundance of Firmicutes and Clostridium. A positive correlation between microbiota and SCFAs was revealed, with Parabacteria and Clostridium being the key microbiota to significantly promote SCFAs. APs promoted the fructose and mannose metabolism by upregulating the gene expression of 17 enzymes, containing fructose-bisphosphate aldolase [EC:4.1.2.13]. Our findings highlight SCFAs-producing Parabacteria were primary degrader of APs, and APs may have prebiotic effects on gut microbiota.
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