Journal
CANCER TREATMENT REVIEWS
Volume 99, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ctrv.2021.102250
Keywords
Mesothelioma; Immune checkpoint inhibitors; Nivolumab; Pembrolizumab; Ipilimumab
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Malignant pleural mesothelioma is a rare and aggressive thoracic malignancy with poor prognosis, but the recent approval of immune checkpoint inhibitors has brought hope for treatment. However, there are still unresolved challenges, such as determining the best upfront immune approach and utilizing predictive biomarkers.
Malignant pleural mesothelioma (MPM) is a rare and orphan thoracic malignancy, with a poor prognosis as the majority of patients are diagnosed with unresectable MPM, with no significant improvements in the therapeutic strategy for over a decade. However, the recent approval of immune checkpoint inhibitors (ICI) in treatment naive patients with unresectable MPM marks a significant step forward and hope for the treatment of this disease. In this narrative review, we discuss the biological rationale to use ICI in the treatment of MPM. We summarize the current evidence for the efficacy of ICI in MPM and discuss several unresolved challenges regarding the use of ICI in this disease, such as the best upfront immune approach in MPM (ICI versus ICI plus chemotherapy), the optimal sequential treatment strategy according to the first-line treatment, and the potential role of predictive biomarkers.
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