Journal
CANCER SCIENCE
Volume 112, Issue 10, Pages 4087-4099Publisher
WILEY
DOI: 10.1111/cas.15083
Keywords
apoptosis; colorectal cancer; ErbB2; IGF2BP2; invasion; m6A; migration; proliferation; YAP
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Funding
- National Natural Science Foundation of China [81802084]
- Shanghai Post-doctoral Excellence Program [2020409]
- Postdoctoral Science Foundation of China
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IGF2BP2 activates ErbB2 expression by recognizing the m6A modification of YAP, thus promoting proliferation and invasion of CRC cells while inhibiting apoptosis.
To explore the effect of insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) on colorectal cancer (CRC) by recognizing the m6A modification of YAP mRNA thus activating ErbB2 expression. High expressions of IGF2BP2, YAP, and ErbB2 promoted the proliferation, migration and invasion of CRC cells and reduced their apoptosis. IGF2BP2 recognized the m6A on YAP mRNA and promoted the translation of mRNA. YAP regulated ErbB2 expression by promoting TEAD4 enrichment in ErbB2 promoter region. Therefore, IGF2BP2 promoted the expression of ErbB2 to enhance the proliferation, invasion and migration of CRC cells, to repress cell apoptosis, and to promote solid tumor formation in nude mice. IGF2BP2 activates the expression of ErbB2 by recognizing the m6A of YAP, thus affecting the cell cycle of CRC, inhibiting cell apoptosis, and promoting proliferation.
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