Journal
CANCER SCIENCE
Volume 112, Issue 8, Pages 3388-3400Publisher
WILEY
DOI: 10.1111/cas.15021
Keywords
breast cancer; cancer driver genes; protein microarray; tumor-associated antigens; tumor-associated autoantibodies
Categories
Funding
- Major Project of Science and Technology in Henan Province [161100311400]
- Zhengzhou Major Project for Collaborative Innovation [18XTZX12007]
- National Science and Technology Major Project of China [2018ZX10302205]
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The study identified 12 TAAb with potential for BC detection, particularly in distinguishing BC from healthy controls (HC).
Tumor-associated autoantibodies (TAAb) could be serological tumor markers. This study aims to discover novel TAAb signatures for breast cancer (BC) detection. The protein microarray was used to identify candidate TAAb, which were further validated in 1197 sera from BC, benign breast diseases (BD), and healthy controls (HC) by enzyme-linked immunosorbent assay. In addition, 319 preoperative and postoperative sera were evaluated. A panel was determined using four different classifiers. Twelve TAAb were identified with frequencies of 15.8%-59.2%; their levels were significantly decreased in postoperative sera compared to those in preoperative sera (P < .05). A panel with six TAAb was developed and evaluated. The area under the curve (AUC) was 0.879 (74.3% sensitivity, 91.9% specificity) and 0.865 (69.7% sensitivity, 91.7% specificity) for distinguishing BC from HC in the training set and test set, respectively. The panel had an AUC of .884 (71.2% sensitivity, 90.5% specificity) for discriminating BC from BD. For identifying BC from all controls (HC+BD), the AUC was .916 (78.9% sensitivity, 90.2% specificity). The AUC of the panel was .920 and .934 for distinguishing stage I-II and age < 50 BC from HC, respectively. These identified TAAb have the potential to provide a non-invasive approach to detect BC.
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