Journal
CANCER SCIENCE
Volume 112, Issue 10, Pages 3972-3978Publisher
WILEY
DOI: 10.1111/cas.15112
Keywords
ATG8-family proteins; autophagy; liquid-liquid phase separation; selective autophagy; selective autophagy receptors
Categories
Funding
- Japan Society for the Promotion of Science [21H00477, 20K06644, 19H05706]
- Ministry of Education, Culture, Sports, Science and Technology
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [20K06644, 21H00477, 19H05706] Funding Source: KAKEN
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Selective autophagy, which degrades specific targets in a selective manner, plays a crucial role in maintaining cellular homeostasis by regulating diverse cellular functions.
While starvation-induced autophagy is thought to randomly degrade cellular components, under certain circumstances autophagy selectively recognizes, sequesters, and degrades specific targets via autophagosomes. This process is called selective autophagy, and it contributes to cellular homeostasis by degrading specific soluble proteins, supramolecular complexes, liquid-liquid phase-separated droplets, abnormal or excess organelles, and pathogenic invasive bacteria. This means that autophagy, like the ubiquitin-proteasome system, strictly regulates diverse cellular functions through its selectivity. In this short review, we focus on the mechanism of selective autophagy, which is rapidly being elucidated.
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