4.7 Article

Aging of the progenitor cells that initiate prostate cancer

Related references

Note: Only part of the references are listed.
Article Cell & Tissue Engineering

Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function

Els Mansell et al.

Summary: This study demonstrates that mitochondrial membrane potential (MMP) plays a crucial role in old hematopoietic stem cells (HSCs) and its pharmacological manipulation can alter transcriptional programs with beneficial consequences for function. Enhancing MMP in old HSCs can increase engraftment potential upon transplantation and reverse myeloid-biased peripheral blood output.

CELL STEM CELL (2021)

Article Cell Biology

Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation

Yang Zhang et al.

Summary: Forced expression of glucose-6-phosphate dehydrogenase (G6PD) leads to anchorage-independent growth in vitro and tumorigenicity in animals, by increasing NADPH pool, bolstering antioxidant defense, and promoting nucleotide precursor levels. Normal cells have limited capacity for redox balance and nucleotide synthesis, and overcoming this limit might represent a key aspect of oncogenic transformation.

CELL METABOLISM (2021)

Article Genetics & Heredity

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

David Conti et al.

Summary: The study identified 86 new genetic risk variants associated with prostate cancer, bringing the total known risk variants to 269. The top genetic risk score decile showed different odds ratios for men of European, African, and East Asian ancestries, highlighting the role of germline variation and providing a potential approach for personalized risk prediction.

NATURE GENETICS (2021)

Article Multidisciplinary Sciences

Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells

Manjunatha Shivaraju et al.

Summary: Recent research has shown that airway basal stem cells have the ability to sense hypoxia and differentiate into solitary NE cells, which secrete a protective peptide called CGRP to mitigate hypoxic injury. This mechanism helps to explain the role of NE cells in the respiratory system and their response to environmental stimuli.

SCIENCE (2021)

Article Multidisciplinary Sciences

Polygenic hazard score is associated with prostate cancer in multi-ethnic populations

Minh-Phuong Huynh-Le et al.

Summary: The study found that a polygenic hazard score can risk-stratify men for prostate cancer in a multi-ethnic dataset, with significant and effective associations observed across different genetic ancestries.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Sox2 is necessary for androgen ablation-induced neuroendocrine differentiation from Pten null Sca-1+ prostate luminal cells

Oh-Joon Kwon et al.

Summary: Sox2 plays a crucial role in the neuroendocrine differentiation of prostate adenocarcinoma. Both Sca-1(+) and Sca-1(-) luminal cells in the mouse prostate are susceptible to oncogenic transformation induced by Pten loss. Tumors derived from Sca-1(+) cells show resistance to castration and are more likely to undergo castration-induced neuroendocrine differentiation.

ONCOGENE (2021)

Article Multidisciplinary Sciences

Divergent mutational processes distinguish hypoxic and normoxic tumours

Vinayak Bhandari et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Increasing ovarian NAD+ levels improve mitochondrial functions and reverse ovarian aging

Qingling Yang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

Article Multidisciplinary Sciences

Regenerative potential of prostate luminal cells revealed by single-cell analysis

Wouter R. Karthaus et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

A genomic and epigenomic atlas of prostate cancer in Asian populations

Jing Li et al.

NATURE (2020)

Article Multidisciplinary Sciences

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

Nicole Almanzar et al.

NATURE (2020)

Article Endocrinology & Metabolism

Urethral luminal epithelia are castration-insensitive cells of the proximal prostate

Diya B. Joseph et al.

PROSTATE (2020)

Article Cell & Tissue Engineering

The Sca-1+and Sca-1-mouse prostatic luminal cell lineages are independently sustained

Oh-Joon Kwon et al.

STEM CELLS (2020)

Article Multidisciplinary Sciences

Age-induced accumulation of methylmalonic acid promotes tumour progression

Ana P. Gomes et al.

NATURE (2020)

Article Multidisciplinary Sciences

Quantifying the influence of mutation detection on tumour subclonal reconstruction

Lydia Y. Liu et al.

NATURE COMMUNICATIONS (2020)

Article Geriatrics & Gerontology

The Plasma NAD+ Metabolome Is Dysregulated in Normal Aging

James Clement et al.

REJUVENATION RESEARCH (2019)

Article Urology & Nephrology

Molecular Hallmarks of Multiparametric Magnetic Resonance Imaging Visibility in Prostate Cancer

Kathleen E. Houlahan et al.

EUROPEAN UROLOGY (2019)

Article Multidisciplinary Sciences

Stem cell competition orchestrates skin homeostasis and ageing

Nan Liu et al.

NATURE (2019)

Article Cell Biology

Expansion of Luminal Progenitor Cells in the Aging Mouse and Human Prostate

Preston D. Crowell et al.

CELL REPORTS (2019)

Article Multidisciplinary Sciences

The landscape of somatic mutation in normal colorectal epithelial cells

Henry Lee-Six et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

Genome-wide germline correlates of the epigenetic landscape of prostate cancer

Kathleen E. Houlahan et al.

NATURE MEDICINE (2019)

Article Multidisciplinary Sciences

Age-related remodelling of oesophageal epithelia by mutated cancer drivers

Akira Yokoyama et al.

NATURE (2019)

Article Genetics & Heredity

Molecular landmarks of tumor hypoxia across cancer types

Vinayak Bhandari et al.

NATURE GENETICS (2019)

Review Urology & Nephrology

The inflammatory microenvironment and microbiome in prostate cancer development

Karen S. Sfanos et al.

NATURE REVIEWS UROLOGY (2018)

Article Medicine, Research & Experimental

Cellular Constituents of the Prostate Stroma: Key Contributors to Prostate Cancer Progression and Therapy Resistance

Christine Levesque et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2018)

Article Biochemistry & Molecular Biology

The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression

Shadrielle Melijah G. Espiritu et al.

Article Multidisciplinary Sciences

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

Christopher R. Martens et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Somatic mutant clones colonize the human esophagus with age

Inigo Martincorena et al.

SCIENCE (2018)

Article Multidisciplinary Sciences

Impaired immune surveillance accelerates accumulation of senescent cells and aging

Yossi Ovadya et al.

NATURE COMMUNICATIONS (2018)

Article Cell Biology

A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra

Gervaise H. Henry et al.

CELL REPORTS (2018)

Review Oncology

Prostate Luminal Progenitor Cells in Development and Cancer

Dingxiao Zhang et al.

TRENDS IN CANCER (2018)

Review Biochemistry & Molecular Biology

Nrf2, the Master Regulator of Anti-Oxidative Responses

Sandra Vomund et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Oncology

Germline Mutations in the Kallikrein 6 Region and Predisposition for Aggressive Prostate Cancer

Laurent Briollais et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

Article Multidisciplinary Sciences

Genomic hallmarks of localized, non-indolent prostate cancer

Michael Fraser et al.

NATURE (2017)

Article Hematology

Clonal hematopoiesis

Max Jan et al.

SEMINARS IN HEMATOLOGY (2017)

Article Multidisciplinary Sciences

Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories

Renea A. Taylor et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

Mitochondrial mutations drive prostate cancer aggression

Julia F. Hopkins et al.

NATURE COMMUNICATIONS (2017)

Article Oncology

Germline Mutations in the Kallikrein 6 Region and Predisposition for Aggressive Prostate Cancer

Laurent Briollais et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

Review Cell Biology

Regulation of Stem Cell Aging by Metabolism and Epigenetics

Ruotong Ren et al.

CELL METABOLISM (2017)

Article Multidisciplinary Sciences

Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay

Jung Wook Park et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Cell & Tissue Engineering

Basal Progenitors Contribute to Repair of the Prostate Epithelium Following Induced Luminal Anoikis

Roxanne Toivanen et al.

STEM CELL REPORTS (2016)

Article Medicine, General & Internal

Benign prostatic hyperplasia

Bilal Chughtai et al.

NATURE REVIEWS DISEASE PRIMERS (2016)

Review Urology & Nephrology

Testosterone deficiency in the aging male

J. Abram McBride et al.

THERAPEUTIC ADVANCES IN UROLOGY (2016)

Review Cell Biology

Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models

Danielle R. Bruns et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2015)

Article Multidisciplinary Sciences

High burden and pervasive positive selection of somatic mutations in normal human skin

Inigo Martincorena et al.

SCIENCE (2015)

Review Andrology

Lowered testosterone in male obesity: mechanisms, morbidity and management

Mark Ng Tang Fui et al.

ASIAN JOURNAL OF ANDROLOGY (2014)

Article Multidisciplinary Sciences

Prostatic inflammation enhances basal-to-luminal differentiation and accelerates initiation of prostate cancer with a basal cell origin

Oh-Joon Kwon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Cell Biology

NAD+ and sirtuins in aging and disease

Shin-ichiro Imai et al.

TRENDS IN CELL BIOLOGY (2014)

Review Medicine, Research & Experimental

Causes, consequences, and reversal of immune system aging

Encarnacion Montecino-Rodriguez et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Multidisciplinary Sciences

Activation of NF-kappa B Signaling Promotes Growth of Prostate Cancer Cells in Bone

Renjie Jin et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells

Tanya Stoyanova et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Metformin improves healthspan and lifespan in mice

Alejandro Martin-Montalvo et al.

NATURE COMMUNICATIONS (2013)

Article Cell Biology

Multipotent and unipotent progenitors contribute to prostate postnatal development

Marielle Ousset et al.

NATURE CELL BIOLOGY (2012)

Article Oncology

Impact of Age at Diagnosis on Prostate Cancer Treatment and Survival

Seth K. Bechis et al.

JOURNAL OF CLINICAL ONCOLOGY (2011)

Article Biochemical Research Methods

Purification and direct transformation of epithelial progenitor cells from primary human prostate

Andrew S. Goldstein et al.

NATURE PROTOCOLS (2011)

Review Cell Biology

Molecular genetics of prostate cancer: new prospects for old challenges

Michael M. Shen et al.

GENES & DEVELOPMENT (2010)

Article Multidisciplinary Sciences

The Effects of Aging on the Molecular and Cellular Composition of the Prostate Microenvironment

Daniella Bianchi-Frias et al.

PLOS ONE (2010)

Review Multidisciplinary Sciences

Extending Healthy Life Span-From Yeast to Humans

Luigi Fontana et al.

SCIENCE (2010)

Article Multidisciplinary Sciences

Identification of a Cell of Origin for Human Prostate Cancer

Andrew S. Goldstein et al.

SCIENCE (2010)

Article Biochemical Research Methods

Meta-analysis of age-related gene expression profiles identifies common signatures of aging

Joao Pedro de Magalhaes et al.

BIOINFORMATICS (2009)

Article Multidisciplinary Sciences

A luminal epithelial stem cell that is a cell of origin for prostate cancer

Xi Wang et al.

NATURE (2009)

Review Geriatrics & Gerontology

Benign prostatic hyperplasia: age-related tissue-remodeling

G Untergasser et al.

EXPERIMENTAL GERONTOLOGY (2005)

Article Multidisciplinary Sciences

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

JH Suh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Urology & Nephrology

Epidemiology of prostate cancer

ED Crawford

UROLOGY (2003)

Article Multidisciplinary Sciences

Notch-mediated restoration of regenerative potential to aged muscle

IM Conboy et al.

SCIENCE (2003)

Article Medicine, Research & Experimental

Age-associated changes in histology and gene-expression profile in the rat ventral prostate

KM Lau et al.

LABORATORY INVESTIGATION (2003)