4.7 Article

Tumor microenvironment in head and neck squamous cell carcinoma: Functions and regulatory mechanisms

Journal

CANCER LETTERS
Volume 507, Issue -, Pages 55-69

Publisher

ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2021.03.009

Keywords

Tumor microenvironment; HNSCC; Immune cells; Stromal cells; Tumor angiogenesis; Cancer stem cells

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Funding

  1. Natural Science Foundation of Guangdong Province [2018A030313610]
  2. National Natural Science Foundation of China [81872409]

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The tumor microenvironment is crucial for protecting tumor cells from treatment-induced death, but how specific signaling pathways affect the tumor microenvironment in head and neck squamous cell carcinoma remains unknown. Various components in the tumor microenvironment have been shown to play important roles in tumor progression and treatment resistance.
The tumor microenvironment has been recently reported to play a pivotal role in sustaining tumor cells survival and protecting them from immunotherapy and chemotherapy-induced death. It remains largely unknown how the specific signaling pathway exerts the tumor microenvironment in head and neck squamous cell carcinoma though previous studies have elucidated the regulatory mechanisms involve in tumor immune microenvironment, stromal cells, tumor angiogenesis and cancer stem cell. These components are responsible for tumor progression as well as anti-cancer therapy resistance, leading to rapid tumor growth and treatment failure. In this review, we focus on discussing the interaction between tumor cells and the surrounding components for better understanding of anti-cancer treatment ineffectiveness and its underlying molecular mechanisms.

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