Journal
CANCER INVESTIGATION
Volume 39, Issue 6-7, Pages 559-570Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07357907.2021.1933015
Keywords
Osteopontin; alternatively spliced variants; cutaneous squamous cell carcinoma; basal cell carcinoma; absolute quantification; OPN-5 subvariants
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The study evaluated the differential expression of SPP1/osteopontin (OPN) splice variants in nonmelanoma skin cancer compared to normal skin. Higher levels of certain splice variants were found in cutaneous squamous cell carcinomas (cSCCs) and basal cell carcinomas relative to normal skin.
The study evaluated whether SPP1/osteopontin (OPN) splice variants are differentially expressed in nonmelanoma skin cancer compared to normal skin. The absolute number of mRNA molecules of OPN-a predominated in normal skin and nonmelanoma skin cancer compared to OPN-b, OPN-c, and OPN-5. However, mRNAs of OPN-a, OPN-b, and OPN-c were expressed in higher levels in cutaneous squamous cell carcinomas (cSCCs) and basal cell carcinomas relative to normal skin. Additionally, OPN-5 expression was higher than OPN-b and OPN-c, and OPN-c, in normal skin and nonmelanoma skin cancer, respectively. Furthermore, we identified four OPN-5 splice variants, which were cloned and analyzed for protein expression.
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