Journal
CANCER CELL
Volume 39, Issue 10, Pages 1317-1341Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2021.08.006
Keywords
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Categories
Funding
- Israel Science Foundation [2044/17]
- Binational Science Foundation [2013332]
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program [818086]
- Fabrikant-Morse Families Research Fund for Humanity
- Chantal d'Adesky Scheinberg Research Fund
- Moross Integrated Cancer Center
- Rising Tide Foundation
- Jacki and Bruce Barron Cancer Research Scholars' Program
- Israel Cancer Research Fund
- City of Hope (COH)
- Harvey L. Miller Family Foundation
- Leona M. and Harry B. Helmsley Charitable Trust
- Adelis Foundation
- Pearl Welinsky Merlo Scientific Progress Research Fund
- Park Avenue Charitable Fund
- Hanna and Dr. Ludwik Wallach Cancer Research Fund
- Daniel Morris Trust
- Wolfson Family Charitable Trust
- Ben B. and Joyce E. Eisenberg Foundation
- White Rose International Foundation
- Estate of Malka Moskowitz
- Estate of Myron H. Ackerman
- Estate of Bernard Bishin for the WIS-Clalit Program
- Else Kroener Fresenius Foundation
- Jeanne and Joseph Nissim Center for Life Sciences Research
- Aliza Moussaieff
- Miel de Botton
- Vainboim Family
- Alex Davidoff
- V. R. Schwartz Research Fellow Chair
- Swiss Society Institute for Cancer Prevention Research at the Weizmann Institute of Science, Rehovot, Israel
- European Research Council
- Israel Science Foundation
- Israel Ministry of Science and Technology
- Israel Ministry of Health
- Helmholtz Foundation
- Garvan Institute
- European Crohn's and Colitis Organization
- Deutsch-Israelische Projektkooperation
- IDSA Foundation
- Wellcome Trust
- The Women's Foundation
- Directorate for STEM Education
- Division Of Undergraduate Education [2013332] Funding Source: National Science Foundation
- European Research Council (ERC) [818086] Funding Source: European Research Council (ERC)
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The human microbiome is a complex community that interacts symbiotically with the host across various body sites, impacting physiological processes and disease conditions. While the influence of microbiome communities on cancer development and treatment responsiveness is still being unraveled, understanding these interactions may lead to advancements in precision cancer therapeutics.
The human microbiome constitutes a complex multikingdom community that symbiotically interacts with the host across multiple body sites. Host-microbiome interactions impact multiple physiological processes and a variety of multifactorial disease conditions. In the past decade, microbiome communities have been suggested to influence the development, progression, metastasis formation, and treatment response of multiple cancer types. While causal evidence of microbial impacts on cancer biology is only beginning to be unraveled, enhanced molecular understanding of such cancer-modulating interactions and impacts on cancer treatment are considered of major scientific importance and clinical relevance. In this review, we describe the molecular pathogenic mechanisms shared throughout microbial niches that contribute to the initiation and progression of cancer We highlight advances, limitations, challenges, and prospects in understanding how the microbiome may causally impact cancer and its treatment responsiveness, and how microorganisms or their secreted bioactive metabolites may be potentially harnessed and targeted as precision cancer therapeutics.
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