The Correlation Between 18F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography Semiquantitative Parameters and the Clinical Features and Pathological Biological Indexes of Gastric Cancer

Objective: This study aimed to explore the application value of the maximum standard uptake value (SUVmax) of F-18-fluorodeoxyglucose-positron emission tomography/computed tomography (F-18-FDG PET/CT) in gastric cancer. Methods: The data of 164 patients with gastric cancer who had undergone(18)F-FDG PET/CT before a biopsy were collected, and the correlation of SUVmax with clinical stage, pathological differentiation degree, human epidermal growth factor receptor-2 (HER-2) status, and Ki-67 index of gastric cancer was analyzed. Results: The SUVmax of poorly differentiated adenocarcinoma was significantly higher than that of moderately differentiated adenocarcinoma and signet-ring cell carcinoma (p < 0.01), and SUVmax in the well-differentiated adenocarcinoma group was higher than that in the signet-ring cell carcinoma group (p < 0.01). The SUVmax in the HER-2 negative group was higher than that in the HER-2 positive group (p < 0.01). The SUVmax was higher in the Ki-67 high expression group than in the low expression group (p < 0.01), and there was a significant positive correlation between the two (p < 0.01). Conclusion: F-18-FDG PET/CT SUVmax can, to some extent, predict the degree of differentiation, HER-2 status, and Ki-67 index of gastric cancer patients.

Automated summary

This study explored the application value of F-18-fluorodeoxyglucose-positron emission tomography/computed tomography (F-18-FDG PET/CT) SUVmax in gastric cancer, and found that it can predict the pathological differentiation, HER-2 status, and Ki-67 index of gastric cancer patients to some extent.