Facile Synthetic Methods for Diverse N-Arylphenylalanine Derivatives via Transformations of Aryne Intermediates and Cross-Coupling Reactions

Synthesis of diverse N-arylphenylalanine derivatives through sequential transformations of N-arylphenylalanine ester-type platforms is disclosed. The highly functionalized platforms were prepared by an oxidative cross-coupling reaction leaving aryne generating moieties and halogeno groups intact. Great transformability of N-arylphenylalanine ester-type platforms by aryne reactions and cross-coupling reactions allowed us to prepare analogs of bioactive compounds.

Automated summary

The study demonstrates the synthesis of diverse N-arylphenylalanine derivatives through sequential transformations of N-arylphenylalanine ester-type platforms. The highly functionalized platforms exhibit great transformability, allowing for the preparation of analogs of bioactive compounds.