Journal
BRITISH JOURNAL OF NUTRITION
Volume 128, Issue 4, Pages 577-591Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114521003627
Keywords
Flavonoids; Gut microbiota; Bioavailability; Polyphenols; Biological activity; Biotransformation
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Flavonoids are natural polyphenol secondary metabolites widely found in plants and in human diets, exhibiting numerous health benefits. Their interactions with gut microbiota play a crucial role in influencing physiological activities and inducing measurable biological changes and benefits. Understanding these interactions is key to comprehensively grasping the impact of flavonoids on human health.
Flavonoids are natural polyphenol secondary metabolites that are widely produced in planta. Flavonoids are ubiquities in human dietary intake and exhibit a myriad of health benefits. Flavonoids-induced biological activities are strongly influenced by their in situ availability in the human GI tract, as well as the levels of which are modulated by interaction with the gut bacteria. As such, assessing flavonoids-microbiome interactions is considered a key to understand their physiological activities. Here, we review the interaction between the various classes of dietary flavonoids (flavonols, flavones, flavanones, isoflavones, flavan-3-ols and anthocyanins) and gut microbiota. We aim to provide a holistic overview of the nature and identity of flavonoids on diet and highlight how flavonoids chemical structure, metabolism and impact on humans and their microbiomes are interconnected. Emphasis is placed on how flavonoids and their biotransformation products affect gut microbiota population, influence gut homoeostasis and induce measurable physiological changes and biological benefits.
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