Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 194, Issue 2, Pages 403-413Publisher
WILEY
DOI: 10.1111/bjh.17646
Keywords
allogeneic hematopoietic stem cell transplantation; acute lymphoblastic leukemia; relapse and refractory; prognosis
Categories
Funding
- Foundation for Promotion of Cancer Research
- Pfizer
- Japanese Society for Hematology
Ask authors/readers for more resources
The study identified several prognostic risk factors for acute lymphoblastic leukaemia patients undergoing allogeneic haematopoietic stem cell transplantation in non-complete remission status, including age, bone marrow blast count, performance status, HCT-comorbidity index, and disease relapse status, among which bone marrow blast count was the most significant. A predictive scoring system composed of these risk factors effectively stratified patient overall survival rates, emphasizing the importance of blast control before transplantation for better prognosis.
Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is one of the curative treatment options for acute lymphoblastic leukaemia (ALL). However, the outcomes in patients transplanted without complete remission (non-CR) have not yet been fully reported, and detailed analyses are required to identify subgroups in which optimal prognosis is expected and to optimize pre-transplant therapeutic strategies. Hence, we performed a multicentred retrospective cohort study including a total of 663 adult ALL patients transplanted at non-CR status; the median bone marrow (BM) blast counts at HSCT was 13 center dot 2%, and 203 patients (30 center dot 6%) were treated at primary induction failure status. The overall survival (OS) was 31 center dot 1% at two years, and the multivariate analyses identified five prognostic risk factors, including older age (>= 50 years), increased BM blasts (>= 10%), poor performance status, high haematopoietic cell transplantation (HCT)-comorbidity index, and relapsed disease status, among which BM blast was the most significantly related. A predictive scoring system composed of these risk factors clearly stratified OS (15 center dot 6-59 center dot 5% at two years). In conclusion, this is the first large-scale study to analyze the correlation of patient characteristics with post-transplant prognosis in ALL transplanted at non-CR status. The importance of blast control before HSCT should be focused on for better patient prognosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available