Are patients benefiting from participation in the German skin cancer screening programme? A large cohort study based on administrative data

Background The German programme for skin cancer screening was established in 2008 with the aim of reducing skin cancer mortality. However, the effectiveness and risk-benefit ratio of the programme remain unclear. Objectives To compare the mortality rates of patients with melanoma who participate in a screening programme to those who do not. Methods A retrospective cohort study, based on pseudonymized health insurance data of 1 431 327 individuals from Saxony, Germany, was conducted for the period 2010-2016. Patients with prevalent and incident melanoma were defined based on diagnosis, medical procedures and prescriptions. Patients who underwent screening and had a first diagnosis of melanoma within 2 years of screening were assigned to the intervention group. Relative survival and Cox regression were used to assess potential differences in mortality. Results We identified 4552 individuals with prevalent and 2475 individuals with incident melanoma. The percentage of screening participants (n = 1801) who had locoregional (4 center dot 2% vs. 13 center dot 5%) and/or distant metastases (4 center dot 3% vs. 8 center dot 0%), or who were treated with systemic anticancer therapies (11 center dot 6% vs. 21 center dot 8%) was lower vs. nonparticipants (n = 674). Screening participants had significantly better survival rates. The unadjusted Cox model gave a hazard ratio (HR) of 0 center dot 37 [95% confidence interval (CI) 0 center dot 30-0 center dot 46]. After adjusting for named confounders, the effect remained (HR 0 center dot 62, 95% CI 0 center dot 48-0 center dot 80). Conclusions Patients who participated in the screening programme had lower mortality than those who had not undergone screening. However, these findings may result from a healthy screen bias and/or overdiagnosis associated with screening, and not from the screening itself.

Automated summary

The German programme for skin cancer screening was established in 2008 with the aim of reducing skin cancer mortality. A retrospective cohort study in Saxony, Germany found that patients with melanoma who participated in the screening programme had lower mortality rates and better survival rates compared to those who did not participate. However, these benefits may be influenced by factors such as healthy screen bias and overdiagnosis.