4.5 Article

Leveraging genetic data to investigate the effects of interleukin-6 receptor signalling on levels of 40 circulating cytokines

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

Inhibition of interleukin 6 signalling and renal function: A Mendelian randomization study

David K. Ryan et al.

Summary: Genetically proxied inhibition of IL-6 signaling does not show significant associations with eGFR, BUN, or CKD, suggesting that IL-6 signaling may not have large adverse effects on renal function.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2021)

Review Immunology

IL-6 in inflammation, autoimmunity and cancer

Toshio Hirano

Summary: IL-6 is involved in various physiological processes including immune responses and inflammation. It plays a crucial role in chronic inflammation and cytokine storms, such as seen in COVID-19. The IL-6 amplifier, involving NF-kappa B and STAT3, is a key mechanism in promoting uncontrolled inflammatory responses.

INTERNATIONAL IMMUNOLOGY (2021)

Letter Public, Environmental & Occupational Health

Comparison with randomized controlled trials as a strategy for evaluating instruments in Mendelian randomization

Dipender Gill et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2020)

Letter Cardiac & Cardiovascular Systems

Heterogeneity Between Genetic Variants as a Proxy for Pleiotropy in Mendelian Randomization

Dipender Gill

JAMA CARDIOLOGY (2020)

Article Genetics & Heredity

A comparison of robust Mendelian randomization methods using summary data

Eric A. W. Slob et al.

GENETIC EPIDEMIOLOGY (2020)

Letter Virology

Elevated interleukin-6 and severe COVID-19: A meta-analysis

Muhammad Aziz et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

Letter Cardiac & Cardiovascular Systems

Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes A Mendelian Randomization Study

Marios K. Georgakis et al.

CIRCULATION-GENOMIC AND PRECISION MEDICINE (2020)

Review Immunology

How COVID-19 induces cytokine storm with high mortality

Shintaro Hojyo et al.

INFLAMMATION AND REGENERATION (2020)

Article Pharmacology & Pharmacy

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Introduction and Other Protein Targets

Stephen P. H. Alexander et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

Article Medicine, General & Internal

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

P. M. Ridker et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Genetics & Heredity

Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors

Ari V. Ahola-Olli et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2017)

Article Cell Biology

IL-6 in Inflammation, Immunity, and Disease

Toshio Tanaka et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)