Journal
BRITISH JOURNAL OF ANAESTHESIA
Volume 127, Issue 3, Pages 340-343Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.bja.2021.06.025
Keywords
anaesthetic pharmacology; electroencephalogram; hypnotic; neurosteroid; sex difference
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Funding
- US National Institutes of Health [R01-GM126155, P01GM118629, F32-GM137491]
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The study highlights significant sex differences in sensitivity to a novel neurosteroid anesthetic, with female rats being more sensitive than male rats. This underscores the importance of sex differences in anesthesia research and the need for more efforts to understand these disparities.
In this issue of the British Journal of Anaesthesia, Joksimovic and colleagues report significant sex differences in sensitivity to the behavioural and neurophysiological effects of 3 beta-OH, a novel neurosteroid anesthetic. Female rats were more sensitive to the effects of 3 beta-OH than male rats, although the mechanims remain unclear. Sex differences have been understudied in anaesthesia research, and this article by Joksimovic and colleagues emphasizes the need to devote more effort to understanding these differences.
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