Journal
BRAIN RESEARCH BULLETIN
Volume 172, Issue -, Pages 212-219Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2021.04.023
Keywords
Ferroptosis; Traumatic brain injury; Pathology; Treatment
Categories
Funding
- National Natural Science Foundation of China [81671170]
- Natural Science Foundation of Jiangsu Province [BK20201234]
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Traumatic brain injury (TBI) is a global health issue with significant economic burden, where ferroptosis may play a crucial role in its pathophysiology. Inhibition of ferroptosis could potentially improve long-term outcomes of TBI, emphasizing the importance of understanding the association between ferroptosis and TBI for new treatment targets.
Traumatic brain injury (TBI) is a worldwide health problem contributing to significant economic burden. TBI is difficult to treat partly due to incomplete understanding of pathophysiology. Ferroptosis is a type of irondependent programmed cell death which has gained increasing attention due to its possible role in TBI. Current studies have demonstrated that ferroptosis is related to the pathology of TBI, and inhibition of ferroptosis may improve long term outcomes of TBI. Therefore, clarification of the exact association between ferroptosis and traumatic brain injury is necessary and may provide new targets for treatment. This review describes (1) the ferroptosis pathways following traumatic brain injury, (2) the role of ferroptosis during the chronic phase of traumatic brain injury, and (3) potential therapies targeting the ferroptosis pathways.
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