Journal
BRAIN IMAGING AND BEHAVIOR
Volume 16, Issue 2, Pages 738-747Publisher
SPRINGER
DOI: 10.1007/s11682-021-00541-5
Keywords
Bipolar disorder; Voxel-based morphometry; Source-based morphometry; Cognition; Emotional processing
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Funding
- Universita degli Studi di Padova within the CRUI-CARE Agreement
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This study reported widespread gray matter volume alterations in bipolar disorder patients. BD-I showed different GMV features compared to controls, which were associated with illness severity and cognitive function performance. The impaired prefrontal-temporal-occipital network structure was related to deficits in visuospatial processing and emotional processing in BD-I patients.
Widespread regional gray matter volume (GMV) alterations have been reported in bipolar disorder (BD). Structural networks, which are thought to better reflect the complex multivariate organization of the brain, and their clinical and psychological function have not been investigated yet in BD. 24 patients with BD type-I (BD-I), and 30 with BD type-II (BD-II), and 45 controls underwent MRI scan. Voxel-based morphometry and source-based morphometry (SBM) were performed to extract structural covariation patterns of GMV. SBM components associated with morphometric differences were compared among diagnoses. Executive function and emotional processing correlated with morphometric characteristics. Compared to controls, BD-I showed reduced GMV in the temporo-insular-parieto-occipital cortex and in the culmen. An SBM component spanning the prefrontal-temporal-occipital network exhibited significantly lower GMV in BD-I compared to controls, but not between the other groups. The structural network covariance in BD-I was associated with the number of previous manic episodes and with worse executive performance. Compared to BD-II, BD-I showed a loss of GMV in the temporal-occipital regions, and this was correlated with impaired emotional processing. Altered prefrontal-temporal-occipital network structure could reflect a neural signature associated with visuospatial processing and problem-solving impairments as well as emotional processing and illness severity in BD-I.
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