4.6 Review

Cholesterol metabolism related genes in osteoarthritis

Related references

Note: Only part of the references are listed.
Article Rheumatology

Association of Serum Low-Density Lipoprotein, High-Density Lipoprotein, and Total Cholesterol With Development of Knee Osteoarthritis

Jessica L. Schwager et al.

Summary: The study finds no significant association between total serum cholesterol, LDL, HDL, and the risk of knee osteoarthritis (OA) or its outcomes.

ARTHRITIS CARE & RESEARCH (2022)

Article Multidisciplinary Sciences

Adipose tissue is a critical regulator of osteoarthritis

Kelsey H. Collins et al.

Summary: Obesity is closely related to osteoarthritis, but the specific mechanisms by which it leads to OA are complex. Research shows that adipose tissue plays a critical role in the pathophysiology of OA, and paracrine signaling from fat may be a mediator of joint degeneration.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Review Medicine, General & Internal

Diagnosis and Treatment of Hip and Knee Osteoarthritis A Review

Jeffrey N. Katz et al.

Summary: Osteoarthritis is a prevalent joint disease that can impact various joints, with risk factors including age, gender, obesity, genetics, and major joint injury. Treatment typically involves exercise, weight management, education, and medication therapy. Advanced cases may require surgical intervention for pain relief and improved function.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Medicine, Research & Experimental

Vaspin regulated cartilage cholesterol metabolism through miR155/LXRα and participated in the occurrence of osteoarthritis in rats

Hangyuan He et al.

Summary: This study explored the role of Vaspin and cholesterol metabolism in osteoarthritis (OA) through in vitro and in vivo experiments. It was found that Vaspin reversed IL-1 beta-induced expression changes in chondrocytes, but miR155 mimics could reverse the effects on cholesterol efflux pathway. Furthermore, in a rat OA model, the decreased expression of cholesterol efflux related genes was associated with reduced Vaspin levels and increased miR155 expression in OA knee cartilage.

LIFE SCIENCES (2021)

Article Rheumatology

Statins and lower mortality in rheumatic diseases: An effect of immortal time bias?

Devin Abrahami et al.

Summary: This study evaluated the presence of immortal time bias in observational studies investigating the effectiveness of statins in patients with rheumatic diseases. The findings suggest that bias in observational studies may explain the discrepancy in findings with randomized controlled trials on the effectiveness of statins in patients with rheumatic diseases. Future observational studies should aim to avoid immortal time bias.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2021)

Review Orthopedics

Osteoarthritis year in review 2019: genetics, genomics and epigenetics

L. N. Reynard et al.

OSTEOARTHRITIS AND CARTILAGE (2020)

Review Endocrinology & Metabolism

Bidirectional association between metabolic syndrome and osteoarthritis: a meta-analysis of observational studies

Sheng-Yao Liu et al.

DIABETOLOGY & METABOLIC SYNDROME (2020)

Review Rheumatology

Interplay between genetics and epigenetics in osteoarthritis

Sarah J. Rice et al.

NATURE REVIEWS RHEUMATOLOGY (2020)

Review Medicine, Research & Experimental

The role of oxidation of low-density lipids in pathogenesis of osteoarthritis: A narrative review

Kazuhiko Hashimoto et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2020)

Article Multidisciplinary Sciences

The CH25H-CYP7B1-RORα axis of cholesterol metabolism regulates osteoarthritis

Wan-Su Choi et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

Simvastatin promotes restoration of chondrocyte morphology and phenotype

Kenya Terabe et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2019)

Review Cardiac & Cardiovascular Systems

HDL and Reverse Cholesterol Transport Basic Mechanisms and Their Roles in Vascular Health and Disease

Mireille Ouimet et al.

CIRCULATION RESEARCH (2019)

Review Medicine, General & Internal

Osteoarthritis

David J. Hunter et al.

LANCET (2019)

Article Rheumatology

Statin Use and Knee Osteoarthritis Outcomes: A Longitudinal Cohort Study

Nicola Veronese et al.

ARTHRITIS CARE & RESEARCH (2019)

Article Cell Biology

Age and frailty as risk factors for the development of osteoarthritis

Melissa S. O'Brien et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2019)

Review Agriculture, Dairy & Animal Science

Diet-Induced Rabbit Models for the Study of Metabolic Syndrome

Wilson M. Lozano et al.

ANIMALS (2019)

Article Cell & Tissue Engineering

Attenuation of osteoarthritis progression in mice following intra-articular administration of simvastatin-conjugated gelatin hydrogel

Toshikazu Tanaka et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2019)

Review Genetics & Heredity

Chromatin accessibility and the regulatory epigenome

Sandy L. Klemm et al.

NATURE REVIEWS GENETICS (2019)

Article Biochemistry & Molecular Biology

Protective effects of atorvastatin against high glucose-induced nuclear factor-κB activation in cultured C28I2 chondrocytes

Kobra Bahrampour Juybari et al.

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2019)

Review Rheumatology

Is osteoarthritis one disease or a collection of many?

Leticia A. Deveza et al.

RHEUMATOLOGY (2018)

Article Cell Biology

Studying microRNAs in osteoarthritis: Critical overview of different analytical approaches

Varvara Trachana et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2018)

Review Orthopedics

Osteoarthritis biomarkers: year in review

F. E. Watt

OSTEOARTHRITIS AND CARTILAGE (2018)

Article Orthopedics

Variable cartilage degradation in mice with diet-induced metabolic dysfunction: food for thought

A. E. Kozijn et al.

OSTEOARTHRITIS AND CARTILAGE (2018)

Review Orthopedics

Systemic and local adipose tissue in knee osteoarthritis

J. Chang et al.

OSTEOARTHRITIS AND CARTILAGE (2018)

Review Orthopedics

Osteoarthritis year in review 2017: clinical

A. E. Nelson

OSTEOARTHRITIS AND CARTILAGE (2018)

Article Rheumatology

Risk of Incident Osteoarthritis of the Hand in Statin Initiators: A Sequential Cohort Study

Theresa Burkard et al.

ARTHRITIS CARE & RESEARCH (2018)

Review Nutrition & Dietetics

Molecular Pathways Underlying Cholesterol Homeostasis

Milessa Silva Afonso et al.

NUTRIENTS (2018)

Review Biochemistry & Molecular Biology

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

Michael S. Brown et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87 (2018)

Article Biochemistry & Molecular Biology

Suppression of ABCD2 dysregulates lipid metabolism via dysregulation of miR-141:ACSL4 in human osteoarthritis

Sujeong Park et al.

CELL BIOCHEMISTRY AND FUNCTION (2018)

Review Medicine, Research & Experimental

The complex landscape of microRNAs in articular cartilage: biology, pathology, and therapeutic targets

Helal Endisha et al.

JCI INSIGHT (2018)

Article Biochemistry & Molecular Biology

Dietary Fats and Osteoarthritis: Insights, Evidences, and New Horizons

Sunderajhan Sekar et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2017)

Article Rheumatology

Cam Deformity and Acetabular Dysplasia as Risk Factors for Hip Osteoarthritis

Fatemeh Saberi Hosnijeh et al.

ARTHRITIS & RHEUMATOLOGY (2017)

Article Biochemistry & Molecular Biology

Protective effects of mitochondria-targeted antioxidants and statins on cholesterolinduced osteoarthritis

Saba Farnaghi et al.

FASEB JOURNAL (2017)

Article Genetics & Heredity

Nuclear receptors regulate lipid metabolism and oxidative stress markers in chondrocytes

Anusha Ratneswaran et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2017)

Article Biochemical Research Methods

Screening and Validation of Novel Biomarkers in Osteoarticular Pathologies by Comprehensive Combination of Protein Array Technologies

Alvaro Sierra-Sanchez et al.

JOURNAL OF PROTEOME RESEARCH (2017)

Letter Medicine, General & Internal

ANGPTL3 Inhibition in Homozygous Familial Hypercholesterolemia

Daniel Gaudet et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Medicine, General & Internal

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease

F. E. Dewey et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Multidisciplinary Sciences

Serum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study

M. Garcia-Gil et al.

SCIENTIFIC REPORTS (2017)

Review Cardiac & Cardiovascular Systems

Pleiotropic Effects of Statins on the Cardiovascular System

Adam Oesterle et al.

CIRCULATION RESEARCH (2017)

Review Cardiac & Cardiovascular Systems

Association between osteoarthritis and cardiovascular disease: Systematic review and meta-analysis

Andrew J. Hall et al.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2016)

Article Rheumatology

Regulation of Cholesterol Homeostasis by Hedgehog Signaling in Osteoarthritic Cartilage

Shabana Amanda Ali et al.

ARTHRITIS & RHEUMATOLOGY (2016)

Review Biochemistry & Molecular Biology

Inter-relations between osteoarthritis and metabolic syndrome: A common link?

S. Le Clanche et al.

BIOCHIMIE (2016)

Review Genetics & Heredity

The molecular hallmarks of epigenetic control

C. David Allis et al.

NATURE REVIEWS GENETICS (2016)

Editorial Material Rheumatology

Insulin Resistance: Releasing the Brakes on Synovial Inflammation and Osteoarthritis?

Timothy M. Griffin et al.

ARTHRITIS & RHEUMATOLOGY (2016)

Article Medicine, General & Internal

Osteoarthritis

Johanne Martel-Pelletier et al.

NATURE REVIEWS DISEASE PRIMERS (2016)

Article Medicine, General & Internal

Osteoarthritis

S. Glyn-Jones et al.

LANCET (2015)

Article Medicine, General & Internal

Efficacy and Safety of Alirocumab in Reducing Lipids and Cardiovascular Events

Jennifer G. Robinson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Editorial Material Orthopedics

A new prescription for growth? Statins, cholesterol and cartilage homeostasis

J. R. Bush et al.

OSTEOARTHRITIS AND CARTILAGE (2015)

Article Biochemical Research Methods

Comparative proteomic analysis of hypertrophic chondrocytes in osteoarthritis

Konstantinos C. Tsolis et al.

CLINICAL PROTEOMICS (2015)

Letter Rheumatology

Use of statins is associated with a lower prevalence of generalised osteoarthritis

A. M. Valdes et al.

ANNALS OF THE RHEUMATIC DISEASES (2014)

Article Rheumatology

The epidemiology of osteoarthritis

Victoria L. Johnson et al.

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY (2014)

Article Endocrinology & Metabolism

Metabolic Syndrome

Susan L. Samson et al.

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (2014)

Article Rheumatology

Proteomic profiling and functional characterization of early and late shoulder osteoarthritis

John Paul Wanner et al.

ARTHRITIS RESEARCH & THERAPY (2013)

Review Rheumatology

Osteoarthritis: A disease of the joint as an organ

Richard F. Loeser et al.

ARTHRITIS AND RHEUMATISM (2012)

Article Orthopedics

High dietary fat and the development of osteoarthritis in a rabbit model

A. M. Brunner et al.

OSTEOARTHRITIS AND CARTILAGE (2012)

Article Multidisciplinary Sciences

Central Role of SREBP-2 in the Pathogenesis of Osteoarthritis

Fotini Kostopoulou et al.

PLOS ONE (2012)

Article Rheumatology

Diabetes-induced osteoarthritis: from a new paradigm to a new phenotype

Francis Berenbaum

ANNALS OF THE RHEUMATIC DISEASES (2011)

Article Medicine, General & Internal

Osteoarthritis: an update with relevance for clinical practice

Johannes W. J. Bijlsma et al.

LANCET (2011)

Review Biochemistry & Molecular Biology

Lipid metabolism and osteoarthritis: Lessons from atherosclerosis

Vasiliki Gkretsi et al.

PROGRESS IN LIPID RESEARCH (2011)

Article Orthopedics

Impaired Expression of Genes Regulating Cholesterol Efflux in Human Osteoarthritic Chondrocytes

Aspasia Tsezou et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2010)

Article Biochemistry & Molecular Biology

Small Discoidal Pre-β1 HDL Particles Are Efficient Acceptors of Cell Cholesterol via ABCA1 and ABCG1

Elda Favari et al.

BIOCHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux

Sandhya Sankaranarayanan et al.

JOURNAL OF LIPID RESEARCH (2009)

Article Medicine, General & Internal

Increased Prevalence of Metabolic Syndrome in Individuals with Osteoarthritis: An Analysis of NHANES III Data

Rajitkanok Amy Puenpatom et al.

POSTGRADUATE MEDICINE (2009)

Article Health Care Sciences & Services

Prevalence of musculoskeletal pain and statin use

Catherine Buettner et al.

JOURNAL OF GENERAL INTERNAL MEDICINE (2008)

Article Orthopedics

Gene expression profiling of chondrocytes from a porcine impact injury model

M. S. Ashwell et al.

OSTEOARTHRITIS AND CARTILAGE (2008)

Article Rheumatology

Do metabolic factors add to the effect of overweight on hand osteoarthritis? The Rotterdam Study

S. Dahaghin et al.

ANNALS OF THE RHEUMATIC DISEASES (2007)

Article Biochemistry & Molecular Biology

Fatty acid transport in articular cartilage

Kenton Paul Arkill et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2006)

Article Biochemistry & Molecular Biology

Role of cholesterol in the regulation of growth plate chondrogenesis and longitudinal bone growth

SF Wu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and insigs

CM Adams et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Pharmacology & Pharmacy

LXRs; Oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis

PA Edwards et al.

VASCULAR PHARMACOLOGY (2002)

Review Multidisciplinary Sciences

Cell biology - How cells handle cholesterol

K Simons et al.

SCIENCE (2000)

Article Cell Biology

Role of LXRs in control of lipogenesis

JR Schultz et al.

GENES & DEVELOPMENT (2000)