Journal
EXPERIMENTAL HEMATOLOGY
Volume 44, Issue 6, Pages 451-457Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.exphem.2016.03.004
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Funding
- TOP grant from The Netherlands Organization for Health Research and Development, ZonMw Project [40-00812-98-09050]
- TOP grant from The Netherlands Organization for Health Research and Development, ZonMW E-RARE Project [40-41900-98-020]
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The Wnt signaling pathway is an evolutionary conserved pathway that is involved in the development of almost every organ system in the body and provides self-renewal signals for most, if not all, adult stem cell systems. In recent years, this pathway has been studied by various research groups working on hematopoietic stem cells, resulting in contradicting conclusions. Here, we discuss and interpret the results of these studies and propose that Wnt dosage, the source of hematopoietic stem cells, and interactions with other pathways explain these disparate results. (C) 2016 ISEH - International Society for Experimental Hematology. Published by Elsevier Inc.
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